NorthWest Biotherapeutics Inc (NWBO)

[Doktornolittle]

"Koman says - I have no idea why choosing multiple tumor injections make any sense at all as the next step.

Perhaps different tumors, although in the same body, express different antigens, and injecting each would cover more possible antigen expressions."

Maybe so. But I would think that most of the time they would be the same animal.

Injecting more than one of them would likely generate a larger systemic response because it would generate more activated DC's and probably involve more lymph nodes.

In addition to the simple linear increase in the systemic response, cluing the body that there are mets might invoke a disproportionate increase in the systemic response as the hunt for mets gets very serious.

It's unknown territory. Testing such possibilities makes sense to me.

And if I were a patient, I would want them to inject every tumor, of course, if they could. But I do understand why they must first check to see if that is even necessary. Just hope that at some point, if the systemic response is not dramatic, that they do follow through with further injections. Even if that had to be at a low dose.