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Well here we go again..
IF Anavex is NOT going to "BE"the target of the investigation wouldn't i t be logical to assume that is because Anavex WAS one of the targets being reviewed? How else would Anavex be exonerated?
Either way THIS IS VERY POSITIVE NEWS as it ALLOWS..
FDA, PARTNERSHIP..Etc..GREEN LIGHT to move Forward!
We CAN agree on that can't we? Or is the light more like a bluish - yellow?
there are 30 MILLION shares in Public, then there were 15 MILLION shares in Public..Investors held until the Short Cabal got to work..that is not manipulation..that is greed and hope..Maniputlaion is the coordinated effort..you know like the SHORT CABAL..that continues to ATTACK othe BIO_PHARM stock exactly the SAME WAY..
Apparently Anavex was the Target of Investigation..Man our Government is messed up! How long did that Investigation take? Let me see your e-mails and phone..Ok we are gone..goood luck with treating Alzheimers..Takes about two days..Ridiculous. Go find some bad guys SEC..oh yeah..Corey Renauer somehow got paid to write 5000 distorted articles about Anavex about the same time rosen Law Firm and 5000 other Law Firms sued about the same time Shrkeilia dn Fuerstein and 5000 other "Investment Advisors" wrote half truth articles..You even had Wndy or Cindy from the "STREET" CALL OUR CEO!
But HEY! thanks for moving on.and letting us know..OUR TAX DOLLARS AT WORK!
Number 2: HOW DOES ANAVEX and the good DR. DO IT? $2,000,000?
BP spends that BLOWING THEIR NOSE!
We are TRULY BLESSED!
Go good Dr. Go..You DESERVE EVERY STINKING PENNY OF THAT RAISE!
Now go get us a great partnership to pay for Phase 3 !
The Partnership route makes sense as the Short Cabal has successfully made Capital Market expensive with their lies and deceptions..
No One will forget the Motley Fool's never ending Corey Renauer Put Down articles..made to look like Research Coverage..or the Lawsits(one investor with 2 shares) advertised for a MONTH by 30 Different Law Firms..or the Shkrkeili Hate..or Adam Fuerstiein ..ALL DELIVERING LIKE A CHORUS!
Some on here forget..The Short Cabal has not left Anavex..They are just waiting..____________not a nice descriptive word ..
A partnership makes sense as the Co. did not by appearance Sell and Stock under the Lincoln Park Agreement..so..How else are they going to pay for Phase 3?
Rett Syndrome Phase 2/3 may be paid by Rett Syndrome Group..
Not TRUE Again..
Float Size generally refers to the % of STock that trades in the
PUBLIC FLOAT..THEY "FLOATED" THIS STOCK TO RAISE MONEY!
Millions of shares traded hands in one day proving that it is not a LOW FLOAT STOCK!
The Volatlity of the Stock has little or nothing to do with FLOAT..
It has to do with RISK FACTORS involved in BIO-PHARM that have a 99% FAIL RATE..aargh
IMO Anavex does not trade like a tightly held stock,(why Shorts can manipulate) whole other discussion, so it does not quack or walk or behave anything like a duck..People buy it on hope and greed and sell it on fear and loss..it trades like a company with a lot of stock in Public Hands..period..We are HOPING it becomes a tighly held - Low Float stock..but as of this moment..we are rooting for buyers of 200,000 shares a day to keep Anavex from going lower..those buyers are probably short sellers covering..and some value buyers and MAYBE some peopel adding to their positions..But my guess is many Longs are waiting for Phase 3 declaration or Rett Syndrome Phase 3 or PK News from Michael J Fox PK news..
Lowfloat Stocks lists stocks with under a 10,000,000 share float.
At any given point Anavex may trade that in one day..
not a low float stock.based on Potential of an AD treatment.
we certainly HOPE anavex becomes an extremely low float stock..
Until then..it's not..
I have two definitions for
Low FLoat " Stocks..
One definition is that there simply are NOT THAT MANY SHARES ISSUED or OUTSTANDING..Anavex with 35,000,000 shares issued and outstanding in my book does NOT QUALIFY as a low FLOAT STOCK..
#2..would be even IF , a fair amount of Stock were Authorized, Issued and Outstanding..say like 35,000,000 shares..IF Insiders(Family-Owner-Trust-Employees) Owned a 30-50% or higher stake,,THEN I would consider Anavex a Low Float stock.
AS a Super Majority of Anavex Stock Trades I would NOT COnsider this a low float stock, NOR a tightly held Stock..that is ONE REASON WHY short Cabal so effective..
Not ONLY do you have a Majority of 35 Million Shares availabel to trade..teh Short Cabal may add 1 to 5-6 Million trade shares on any given day.
A Small Float stock would be under 15 Million shares with 10 Million or less trading(IMO)
If someone wre comparing the # of Shares of Anavex and American Registered Stock to an aUstralian Registered stock , THAN I could see where you might call Anavex "Low Float", but since they trade on Different exchanges I don't feel this would be a proper comparison for Investors.
no I DON'T AGREE!
That would be like saying 7 PEOPLE out of 30 SHOW CANCER REMISSION and are walking around perfectly healthy..but we mya dray no conclusions!
We may draw conclusions ..AS A MONOTHERAPY Anavex MAY show REMISSION PROPERTIES in almost 100% Of the PATIENTS! And THAT is ACCOMPLISHED even THOUGH DOSAGE WAS NOT MAXIMIZED!
so the "markets"..
Usually the Short Cabal is tied into the OWNNERSHIP of MANAGEMENT of
the Company to skewer Retail out of money.
It is their own little Skewer the little guy club.
the good Dr. is NOT part of this club.
the Board of Directors is NOT part of this club.
So the CLUB doesn't like this..especially when the Drugs that Anavex has stand to destroy TRILLIONS from the Market Caps of other Drug Companies.
KAPISCHE? Who wants to stand in front of that TRAIN?
The Hedgefunds are against you with AXON..
The Mouthpieces are against you..Heck I think YAHOO literally stopped
their Messagae Boards becasue of Anavex!
You don't see any stories in any Alzheimer Care Organizations..WHY NOT?
WHO DO YOU THINK FUNDS THEM?
So..I mean brother..Hundreds of Millions of dollars is CHUMP CHANGE..
CHUMP CHANGE to these ANIMALS..
You wonder where the Investors are? Getting screamed at
by their Fellow Club Members for Supporting ANAVEX..
That is where they are..
We have some wicked enemies and the good Dr. has to find a way around them..other BIOs have..and so will the good Dr...
Maybe Germany , maybe Japan.who knows..
It takes less than $50 Mill to do phase 3..
and we have all those other IND's...
Retail has not been able to support MC over $200,000,000 ..so just keep that in mind..
Rich people have a lot to lose if Anavex is succesful..they are putting their money where their mouths are..
In some ways we have truly become a sick sockiet and capitlaism has found a new dark hole with the unregulated Short Cabal..
Ladies and Gentleman, I spent hours researching the Placebo effect and commented here upon my findings. it was the Interim 12 WEEK data that showed positive results at 17 weeks, or from 5 weeks to 17 weeks in ADCS-ADL. This is a SAFETY TEST..A2-73 is SAFE. Period.
is ther PK? YES
are there are any positive signs from a non-maximized grouped study to show efficacy from the PK? YES!
Phase 3..
How to pay for it? the important part.yes we will have to give up
somehting..but even more important is ..
WE HAVE SOMETHING EVERYONE WANTS..so they will PAY to be a part of Anavex..
And we will ALL WIN...
helping the body do what it is designed to do..it best..
Anavex
everybody put powder aside..and the next positive news story..
we become RELENTLESS BUYERS! market orders up to $5! haha..just kidding..kinda
Jimmy..that's my point..WE DID HIT A HOMERUN! WE DID SEE REVERSAL!
WTH? It's like BISON over a cliff..
BUY, BUY BUY!
Waiting for my next check..
on any given day IMO there are at least(<1%)200,000 shares that will need to be sold for varying reasons..need cash, other investments..blah, blah blah..
so to maintain a price(support) you need to find a level where you have buyers of 200,000 shares..MINIMUM as this does NOT include Short Sellers..
Who see the LACK of these BUYERS as an opportunity to create fear..and double down..hoping to create more sellers..
The question becomes..where are the BUYERS?
The Data from AAIC is GOOD maybe EVEN GREAT!
Where are the Investment Houses Re-AFFIRMING THEIR BUY RECOMMENDATIONS?
Where are the Traders who Sold High? Oops..Was it ALL SHORT SELLER CABAL that sold high? If that is the case..than this RIGGED MARKET really..really..
GIVES US ALL the OPPORTUNITY TO
ACCUMULATE CHEAP SHARES!
As I re-think the PART B data at 31 Weeks..
This is the Data from a non-optimized PART B..
We Don't even KNOW how many ?Mg of A2-73 the Patients in MonoTherapy were given! Think about that! What IF in the YELOOW BRICK ROAD group of MonoTherapy that rose to 24 on MMSE instead of non-treated Mild to Moderate AD with starting MMSE of 20 at 31 Weeks being MMSE=16..
And WE DON"t EVEN KNOW if THIS GROUP was Maximized?
ARE YOU KIDDING ME? HOW ARE WE THIS CHEAP?
SHORT CABAL..truly ..the ONLY ANSWER..
There is NO WAY LONGS are THIS disappointed in a NON-OPTIMIZED
STUDY that shows MONO-THERAPY OFF THE CHARTS at 31 WEEKS!
NO WAY
Would not a Phase 2/3 also be Fully Funded by Michael J Fox Foundation?
AND all we need is pre-clinical to move forward to Phase2/3, since SAFETY has been established, and Dosage is established for AD,
14 Mg minimum for Action..50Mg Max Tolerated Dosage..
Understood waiting for PK to determine Optimal Dosing and that
PART B is NOT optimally Dosed..Still the question is..
Do ALL(MOST)other IND Trials go straight to Phase 3?
With safety and dosage determined..
Understood with Diseases affecting younger Population that many other factors come into play.
thanks Mike, Great find.
We are so ridiculously cheap.
Guess we are still waiting for the right people
to get on board the ship before we cast off.
Whoever you are..come on..let's go!
thanks sokol
n clinical studies, some sigma-1 receptor agonists, improve cognitive impairment and clinical symptoms in neuropsychiatric diseases. In this article, we review the recent findings on sigma-1 receptor agonists as potential therapeutic drugs for the treatment of cognitive impairment in schizophrenia and psychotic depression.
hey look over here! A2-73..Sigma 1 Agonixt with Muscarinic..
Mighty fine Combo
the beachfront scene currently being paitned in Video is by quick glance, appears to be one of her best!
Thde MSN Link showing Valerie Lynch appears to be a new one..
Beautiful Painting..
so Therapy with a Curative Effect would be the homerun?
Reminder..NOT A TARGETED THERAPY!
LAdies and gentleman..
Everytime the Shrot Cabal destroys the Market Value..
I have to Re-Check my positronic relevance..
Am I an idiot? or is Anavex a Multi-billion dollar venture ALREADY?
I know the value of having a new drug in patients and being proven safe
costs hundreds of millions of dollars..so..that should be a value..
I know that the potential for multiple inications for A2-73 is annually multi-billion..
I know that we have PK..which means are drug creates a chemical response in human beings taht is positive..(they measure the PK by positive response..so to have PK is to have psoitive response...
That Fact has to be worth a LOT.
K know the drug is EASY to take..1 day pill--and that it metablolizes into another very similar drug which elongates it's effect..
VERY Postive and valuable..
I know that the people TAKING THE DRUG were going to start a Revolution if they were not granted CONTINUED ACCESS to the DRUG..
That has to be worth A LOT..Who knows better if the drug is GOOD?
Here is the FUN part that I think ALL OF YOU ..in your Brainiac Status..
Except maybe George..
are forgetting due to the Shrot Cabal's persistant evil..
the SIGMA 1 is in EVERY MAJOR ORGAN NOT JUST CNS..
A2-73 does not just Target CNS..it TARGETS Sigma 1..
We Have the Healthy Cell ENEMA for Dead stuff..
For EYES, For DIGESTION, FOR HEART, FOR..
If we have PK, we have a Mulit-Billion Dollar Venture!
I feel better now..how about you guys and gals?
again bernard,
clarity & succinct wording..
you must be Jesuit Educated!
Boiling Over @ THIS POST: Can Not Believe Bernard said THIS!
Bernard What a simplistic , way of looking at the potential for A2-73.
Are you saying that a Drug that helps CNS Cells more rapidly expell dead materials, and shows the health benefits of such activity would be consumed on a very broad basis, especially if the positive side effects-mood, sleep were dramatically greater than the negative side effects-dizziness? And because of this A2-73 may become the greatest blockbuster drug of all time?
I am sorry..but Bernard..I must tell you
This is the GREATEST POST EVER!-- I tip my cap to you Bernard!
you got the countdown right
Anavex is NOT SPINNING..baby becasue I could have SPUN this TALE of the TAPE ..a LOT BETTER than Anavex! Oh my..They could have broken out that MOnotherapy group of 7 Patients and had a Field Day ..
The Anavex Directors are doing EXACTLY what they are supposed to do ..
with their BUDGET..It is only Millions..NOT HUNDREDS of MILLIONS..
We should be VERY VERY Proud of what they have accomplished with our PITTANCE of CAPITAL..
If you are not..than move along please..
The SHort Cabal has many participants ..many Investors..and how do we say..
Stake Holders that want to TIE and KEEP Anavex DOWN< DOWN < DOWN..
Market Makers, Big Pharma, Short Traders. Hedge Funds..it just goes pathetically on and on..
Go ANAVEX!
if ALL A2-73 did was be an alternative to DNP for those who can not stand the side effects..Anavex is STILL a MULTI_BILLION Business..
Just the FACT that A2-73 has PROVEN SAFE-in helathy control group(phase 1) and now in Target Population(Elderly) AND SHOWN PK variation , AND signs of EFFicacy, POSITIVE RESULTS..
MEANS:
1. THERE MUST BE A PHASE 3! YOU MUST HAVE A PHASE 3..IT IS COMING!
2. ANY, and I mean ..ANY SUCCESS -Depression/Anxiety?Insomnia!- IN PHASE 3 makes A2-73 a MULTI-BILLION Dollar Business!.
IF IT JUST EQUALS DNP in EFFICACY, A2-73 posirve SAFETY Results and LOWSIDE EFFECTs will AUTOMATICALLY COMMAND a PATIENT POPULATION!
The ADCS-ADL Graph for MonoTherapy from 17 Weeks to 31 Weeks declined slightly staying around 70..I think top score of this test is 80..
this is test usually shows a linear decline equal to 1 point per month..
so starting at 70 would end at 64-65 6 months later if "no effect"..
the chart shows almost 70 for Monotherapy A2-73 Group at 6 months..
The Depression Test is pooled per the presentation so very difficult to acsertain differential...BUT the Company has ACCESS to ALL THIS DATA.
So Anavex may UNPOOL the DATA anytime they wish..Cogstate Data was pooled ..
This is going to really make your weekend.
What I got out of your post regarding MMSE is this..
SCORE OF 24 or GREATER = NORMAL!
When one is impaired by Disease and then one is Tested "Normal"
then the agent of that change would be, may be considered:
C_________E
when one argues semantics ..it goes both ways, or there would be no argument.."CURATIVE" As an Adjective..Reversal of properties relational to disease ..
able to cure something, typically disease.
"the curative properties of herbs"
synonyms: healing, therapeutic, medicinal, remedial, corrective, restorative, tonic, health-giving
"the natives have used these curative herbs for centuries"
Making something go away..
Xena..we will disagree forever on this ntil of course ..as we both hope.you agree with me! Becasue neither one of us want me to agree with you....
and that is OK because I do respect much if not all of your other conclusions and observations..
But "curative" is a proper adjective for what the A2-73 Monotherapy MMSE
chart shows from 17 Weeks to 31 Weeks..That is recovery, rec=mission..
that is a curative like response(no period, no exclamation mark)
in another AD Drug Trial, TuaRx Phase 3, the MonoTherapy TAURX(don't know tolerabkiltiy but MODE of ACTION Different than A2-73-so could be new JOINT Therapy) they showed an 85% response in the Monotherapy line(almost 100 pateients) and no response in the Taurx plus Aricept Line..
They don't know for sure ..but they conjecture that Aricept may be removing the drug Taurx from the system before it has a chance to be effective..
This IS YET ANOTHER REASON as a Dr., a Patient, a Caregiver, an Investor.
to review MonoTherapy Data as it relates to A2-73.. and be excited..
IF Aricept IS removing A2-73, what happens when Aricept is not given and the patient only recieves A2-73?
The MMSE Chart from 17 Weeks to 31 Weeks in a2-73 as MONOTHERAPY is UNBELIEVABLY POSITIVE! From 20 to 24..at 6 months staying EVEN is better than current SOC(considering side effects and other A2-73 observed postivies) but going UP is CURATIVE.PERIOD.
A Placebo Line would be expected to be back at the Non-Treated Patient Arm at 12 Weeks..so Instead of an MMSE score of 24..if NO RESPONSE to Treatment were observed we woudl expect thsi Group to be at 16-17!
THAT IS UNBELIEVABLE..
One would speculate that our Recovering Artists were in this pool of Patients..Just guessing..But certainly that would be what charts say.. .
There have been signs of Cognitive Reversal and Curative Responses.
Look at the MMSE Chart from 17 weeks to 31 weeks for A2-73 as a Mono Therapy..That response is absolutely "Curative" for 20% of the Patient Population or 7 out of 32..And I do believe the Company has mentioned Cognitive Reversal..At this point..a CURE ..is not a fair assesment of SAFETY DATA..but there are some incredibly exciting results if you are
one of those 7 people on MonoTherapy..Off the Charts exciting..
I would certainly liked to have seen the good Dr. DRIVE down into those
results a little deeper..maybe even take a peek at their Interim results for 38 and 52 if they have them..
if they do, the short cabal may take it down another $.50 a share for possibly stopping 2 diseases! Shrkeilie will shriek, Fuerstein will fart,
Cory Renauer of Motley Fool will lose 29 Billion again..
can't wait!
i am surprised to still have a post left..
Some Questions:
How long had Patients that were already prescribed Donepizil been taking
that drug? Chances are they were more progressed disease and time wise
with Alzheimers. Getting DNP, with it's side effects, is NOT a no brainer.
DNP may have postive effect over time..but AD marches on..and it would be nice to know how long DNP patients on DNP before start of A2-73.
Sleep is a BIG DEAL for Alzheimers..a BIG DEAL..Especially for Home Care..
an almost 30% of pooled data responded postiviely..with better sleep ..it is a big deal..
That yellow line of A2-73 for MMSE as MonoTherapy ..up 4 pts from 20..Placebo would have been DOWN 2.5 points..
That is a Big Deal..so you score 24 versus 17.5 THAT is a BIG DEAL..
It's only 7 patients BUT..Those are the patients for whom we have a more relatively consistant knowledge over..
Chances are they are Newly Diagnosed(possible they tried Aricept and stopped--possible) but that line..is Truly the HOMERUN I was excited about..We may follow this line for the next three years..AND I am sure MonoTherapy will be an ARM in upcoming Phase 3..
This disease is a beast.
Doubt we will get Interim Data on Magnificient 7..but BP will! and Anavex already KNOWS it..
people are getting better..the Royal Flush is still very much in play with Mono-therapy..other IND's..Don't let emotion of lower price affect reality. Just like you din't let higher price..
..trading stocks..nothing wrong with it..investing is an art..
you can't make shrot cabal stop being wicked..even if is about treating Alzheimers..some people just don't give a rat's petutie about other human beings..
Unabel to shirk Short Cabal ..a Parnership was always more likely anyway.
One might think BP shares the cost/investment in such organizations for just this reason..
very well written and explained post..
the Lincoln Park Financing has some anti-dilutive protections..including a price limit I believe of $3, but it could have been as much as $4 per share that Anavex would not be able to raise Capital below this Share Price..Until it went over again..
So the Partnership is looking more likely..and the BS Short Cabal by driving down the share price has made self funding less likely, in that by driving down the share price a Partnership becomes more likely..probably one of the the main goals of Short Cabal..whoever that is....
Not the good Dr's fault..just many many forces aligned against..
On a side bar note ..the good Dr. took Stock Options in the $6-7 range..
he may know a little more than IR..
Positive news not far away..The Reward still far outweighs the risk,,
Hard to BBBillions ..but I SAY IT GUSTO! BBillIONS! ACCUMULATE!
Like a Police song..
Every Chance I get, Every check I make..I will Accumulate..Anavex!
there you go Kid..
As an astute retail investor once said..
If you are buying something at $.10 on the $100..
don't wait too long to buy it..someone else may come
along and just take all of it for $1 on the $100..
if it is a bag we are holding..owning more of it at a lower price..still leaves us holding a bag..
Anavex is not a bag..PK news from Michael J Fox coming..
Phase 3 Rett Syndrome ..coming soon
Phase 3 Alzheiemrs Coming soon
Phase 2 Depression/Anxiety ..coming soon..
Phase 2 Insomnia coming soon..
Phase 2..Infant Spasm..coming soon..
Phase 2..Epilepsy ..coming soon..
"my, my mr retail investor..that is a lot in your
candy bag.."Siad the Big Bad Short, "why don't you let me
hold that for you, and I will sell it back to you
cheaper. You can trust me..
none of this candy looks very good anyway"