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I saw an expectation of hope in miraculous data be destroyed by short sellers who have other interests at heart other than treating Alzheimer's Diseased Patients successfully. The hoped for numbers regarding A2-73 are difficult to see in pooled data, as I just recently posted a story about 3 SubTypes of Alzheimer Disease sufferers. Not everyone who has ALzheimers is being effected by the disease in the same way, so it would make sense that by pooling data, that the data of those effectively treated with A2-73 would be washed out so to speak, by those who suffer a more aggressive AD. The adaptive trial for 32 Patients did NOT, I repeat Did NOT go to Maximum Therapeutic Dosage for all patients!
The 27 Paitients out of 32 continuing to take A2-73 signed up for an additional 2 Years-3 Years total. I wold hope as the Adapative Trial goes on that any of those patients not equalling the benefits of the A2-73 MonoTherapy Group will be allowed to adapt their medicines accordingly.
We know Insomnia was the number 1 noticed HAMD effect and that insomnia is a $32 Billion Market.
The good Dr. knows we just need to get Anavex in the supermarket, doesn't matter what isle you put it in..people will find it.
well said. We invest in an area that has had a 99% fail rate and worry about terms of addittional funding? We have additional funding! Even more excitedly with the data from Phase 2a Part A and Part B( originally scheduled for 26 Weeks) we know that A2-73 has the possiblitiy to effect Insomnia( $32 Billion Annual US Market), Depression ($? Billion) et al..
these are NOT IND's with 99% Fail Rates!
Our Company has gone from a one and done IND to a Broad ranged Pharmaceutical Co. with possible effective treatment for multiple CNS diseases AND ..let me remind everyone again..
IF A2-73 is effectively engaging the S1 Ligand in the CNS area , chances are A2-73 is also effecting the S1 Ligand in MANY < MANY Other areas of Human Function! Thus creating a Super Drug!
Nowhere are any of these developments reflected in the Value of Anavex!
We are undervalued by..it doesn't matter by how much..
But undervalued stocks after positive developments/announcements
also become overvalued stocks..
keep that in mind!
Wow someone thnks higher prices are imminent ..wonder why?
9 month data?
PK Data?
Rett Sydndrome?
they just need to get A2-73 approved fro ANYTHING..
teh LPC has Anti-Dilution COntrols including no Share sells under a certain stock price..I think it's $4 but it might be $3..
Apostrophe, love your responses to Troll.
Thank You.
I see a combination of Drugs depending upon which stage fo deterioration your brain has reached. If you already suffer accumulation of Tau or Amyloid then A2-73(stabilize and stop making more) and Taurx & Prana to remove depoosits that already exist..
I am no Doc, but seems like a great plan to me..if all safe and safe together..
also..maybe find a way to make neuren work to replace lost neuronal cells..
going back from first 5 week Data release, 7-22 would be approximate end date for 38 WEEK Part B..I imagine we will see a poster presentation released at either a conference or a PR..soon
Guess we may talk about Prana now..Still in Trial with original patients, Still showing effects..still doing well..Has like $28 Million in cash..Market value a little over that ..up recently from $4 rand to $6 range..Dr. MacFarlane appears to have made some correct observations..
A safety test on a DOG(no really ..on a DOG) failed and FDA stuck it to Prana..
We shall see..Prana and A2-73 might be a Might Good Combo..
throw in some Taurx and it's a party!
$70 Billion Worldwide Business estimated for 2019
Market Currently served by Addictive, Psychotic Episodic Medicines
"and are especially excited about the observed reduction in insomnia, a condition correlated with multiple underlying psychiatric diseases,” said Christopher U. Missling, PhD, President and Chief Executive Officer of Anavex.
The Number 1 noted HAMD positive effect, 8 points on HAMD scale with
29% - Experiencing positive reduction in Insomnia..
But hey..keep your shorts on..you ain't seen nothing yet!
Elsevier had an article about 3 different types of AD patients and their separate subtypes. I could not get article to come up again, but with my limited knowledge, the gist of their point is they identified 3 different models of patients that breakdown into Alzheimers and the 3 Models did so with different speed....
So..IF the beginning and middle of AD has different individual causations than it makes sense that there is not going to be ONE DRUG or treatment for EVERYONE..Which means each successful drug is looking to treat a TYPE..
so..SAFETY is the VALUE at this Point.
PK is the VALUE at this point..
The other POSIITVE Responses from Patients and Caregivers.
THe Dramatic Response of SOME PATIENTS may indicate THOSE are
the TYPE for which A2-73 is highly effective.
This was the first article I had seen that divided AD Patients into
subtypes this way and showed speed of deterioration based upon said subtypes.
"Malignant Progression in Parietal-Dominant Atrophy Subtype of Alzheimer’s Disease Occurs Independent of Onset Age
Published online: August 11, 2016
Han Kyu Na, Dae Ryong Kang, Sungsoo Kim, Sang Won Seo, Kenneth M. Heilman, Young Noh, Duk L. Na
Neurobiology of Aging"
As I posted earlier, the 38 Weeks PART B should have been around 7-22-16 and the good Dr mentions this Data in the Quarterly..
PK Update?
Rett Syndrome Phase 2-3?
Come on Doc!
BP deal will be negotiated on Competitive forces, which would include other Deals already Reached(Valuation) , LP will provide a backdrop but have NO relevance to VALUATION..the LP deal has limitation of PRICE, thus Dilutive possibilities are also limited, and since little to no LP Stock was sold before AAIC, I would NOT WORRY about LP dilution..
Any BP deal would be greater than those already offered to other Bio-Pharm Platform Co. as we are in Hu Trials and our Drug has shown Efficacy at Multiple IND's.
Don't let the stock price fool you or those that know not of what they speak.
We are in the Catbird's Seat!
Side effects are obvious and usually immediate: dizzinesss, stomach aches, diarhea, etc..noticeable, uncomfortable, perhaps dangerous..
Safety is the expungement of the drug through normal channels of the body, no increased heart rate, no accumulation of drug..no alarming increase in blood toxins as a reaction..no noticeable body effects which would point to a long term health issue..
Look, ALL OF THIS ANTI-DEPRESSIVE, ANTI_INSOMNIA, ANTI_ANXIETY is ALL TOPPINGS on the CAKE ..UNTIL you stop and think..WAIT A MINUTE..
WE HAVE SAFETY..
We HAVE EASE OF USE..
WE HAVE Little to not side effects..
Um..these ICINGS could ,,almost each and every single one..
BE THEIR OWN CAKE! it is too hard to believe..
and now BP and their paid SHRORT CABAL will be ever the more brutal..
as BP NOW has even MORE TO LOSE..
honestly ..there are parts of the Capitalist System which just scare the living curmudgeon out of me.
What would the leaders of BO do to kill Anavex?
what wouldn't they do? Who wouldn't they bribe?
Who wouldn't they .......? Sometimes I think our drug is too good..
JUST on INSOMNIA Alone Anavex has a Billion Dollar Buisness..
why are we letting these shorts control this Co. like this?
We Longs are better than this..it really is embarrassingQ
https://www.drugs.com/condition/insomnia.html
$32 Billion Insomnia in USA
2019 $76 Billion Insomnia market Worldwide..
Really what are we doing..Accumulate
$76 Billion Worldwide by 2019!
Oh my..don't sleep through this one..
What the heck are we doing? I am at a loss for words..
Where are the Greedy Capitalists?
Search Insomnia and Alzheimers:
https://www.alzinfo.org/articles/poor-sleep-may-be-linked-to-alzheimers-disease/
You will find article after article detailing a connection of one sort or another. If Anavex shows PK for positive Sleep Patterns it is most likely
strongly & positively affecting Alzheimers Disease as well.
Apparently I confused BioScience with BIOSPACE..
Sorry Bioscience this was not intentional, but rather a sign that I need
more sleep.
SOmeone give me some A2-73!
absolutely, and the MonoTherapy Arm MUST be LARGE ENOUGH to be
ALLOW for immediate APPROVAL!
Well written Xena! To the point. Low on Hyperbole and smack talk. Impressive really.
Regurgitate, now be honest, did you speel that correctly the first time or did you need spell check? I got it right the first time!
Well, well well. Bioscience can not even create their own stupid reasons that Anavex is a failure, they simply regurgitate the ignorance of others.
First, let me just say, when a writer describes the Chess Match being waged by the good Dr against Big Pharma, as not being "run smart", you immediately realize the writer's lack of accomplishment at the one skill you would expect a modicum of proficiency, writing.
So it is a take back to spend any further time with the article, but for you, the Anavex believer, and our collective sense of trench warfare humor, i battled forward.
As feared, a complete and total waste of time. All they do is repeat fears of too much spent on G&A. I love Corey Renauer's suggestion that Anavex OWN IT'S OWN LAB! What an IDIOT! But at least Corey ignited his own idiocy, this guy can not even come up with one Short Bash of his own. If he did, I could not find it.
The other bash he brought up was the hit piece from the "Street" or SA that was just published, where they say Anavex doesn't work for AD, the Trial was too small, there was no placebo group, A2-73 only works for Insomnia, etc, etc, etc..
Man the "analysts" would do anything for a Placebo Control Group!
But Alzheimers doesn't neeed a placebo control group, because EVERY SINGLE DRUG GIVEN TO ALZHIEMRS PATIENTS HAS BEEN A PLACEBO CONTROL GROUP!
We KNOW what happens to Alzheimers patients GIVEN ANY DRUG, THEY DIE a miserable and rotten death! Control Placebo group well kiss my irish-hungarian heart, they just don't care.
We don't have to go over the FDA helping design and guide the Phase 2a, nor the fact that the FDA is helping guide the design of Anavex's Phase 3 for Alzheimers.
But I do want to point out some simple obvious points.
When Anavex decided to pool the Data, it meant that those patients who were not responsive at all, would be combined with those patients who did respond. (ALL PATIENTS CONTINUED ON THE DRUG FOR 2 YEAR EXTENSION!)
The non response numbers of a Placebo Group would have fallen 4-6 points over 6 month study, 7-9 Points over 9 months..It is a linear fall for Alzheimer's on two of these tests(ADCS-ADL and MMSE).
After 5 weeks in many previous tests with 1000,0s of Patients in a Placebo Blind Group-they generally all reacted the same- the Placebo Effect was almost nonexistent in previous studies, so any positive effects after 5 weeks are going to be from the PK of OUR DRUG, A2-73!
I don't want to go too deep into the Mono-Therapy data..but from 12 Weeks to 26 weeks after which these 7 patients would have been expected to register a 16-18 on their mmse(from 20) they registered a 24.
I don't know why the stock is going down. Wish it wasn't.
But I am a BIG BELIEVER not just A2-73 as a treatment for Insomnia, a $32 BILLION business, Depression, epilepsy, rett Syndrome, etc..on and on..
BUT I am a HUGE BELIEVER in Anavex as a Mono Therapy.
With the data pooled, and Phase 2a PART A and PART B being a SAFETY test with Efficacy secondaries..and using POOLED DATA..we must simply trust the good Dr. when he says the Combo Therapy shows promise.
Period.
Phase 3, ..Thank you very much.
And we can begin all the other Phase Studies..sooner rather than later please..
And I am for the Immediate Availability of A2-73 for ALL Alzheimer PATIENTS..If A2-73 is SAFE, WE DEMAND THE OPTION TO USE IT!
I should end with some sort of tie -in to the beginning regarding the poorly executed, non-creative hit piece by Bio-Science, but honestly, I am too excited about Anavex to relive the nightmare.
So go on with yourself..
Anti-Depressants:
What keeps Big Pharma up at night you ask?
Anavex DOES!
Antidepressants are drugs used for the treatment of major depressive disorder and other conditions, including dysthymia, anxiety disorders, obsessive compulsive disorder, eating disorders, chronic pain, neuropathic pain and, in some cases, dysmenorrhoea, snoring, migraine, attention-deficit hyperactivity disorder (ADHD), addiction, dependence, and sleep disorders. They can be used alone or in combination with other medications but only when prescribed.
The most important classes of antidepressants are the selective serotonin reuptake inhibitors (SSRIs), serotonin–norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), monoamine oxidase inhibitors (MAOIs), reversible monoamine oxidase A inhibitors (rMAO-A inhibitors), tetracyclic antidepressants (TeCAs), and noradrenergic and specific serotonergic antidepressant (NaSSAs).[1] St John's wort is also used in the treatment of depression.[1][2]
Or you could just take Anavex..and sleep like a baby..
PUMP YOU UP!
I CAN'T SLEEP AT NIGHT, thinking about you baby!
so I only get so many posts a day(my Dr has requested that I not pay for subscription, but rather use my limited number of posts as a "Chaperone" so to speak) and I need to make them count.
Ah COUNT..
I just wanted to COUNT with everyone what a 10% Piece of the Insomnia Market might do for Anavex Stock..
A $32 BILLION Annual Market where almost EVERY DRUG has wicked side effects, Addiciton, Psychotic Reactions, etc, etc, etc..
Capturing 10% of this market with a well tolerated low side effect NON_OPIOID Drug that works..should be doable.
$3.2 Billion Annually..hm..We should give that at least a multiple of 20X right?..I mean you are going to trade 20x a succesful treatment for INSOMNIA..so that takes Anavex to $60 BILLION..
$60,000,000,000 divided by (we sell 10,000,000 shares to raise $$$)
50,000,000 Shares = $1,200/Share..
But WAIT..
We have forgotten the additional $$ from Alzheimers, etc..etc..etc..
At $3 a share anavex might be an excellent risk to reward opportunity..
ya'think?
PUMP YOU UP!
It may be time for Anavex to update their website.
The reasoning behind Anavex Plus may have changed with the Data now being collcted. However ..Anavex will probably waitn until the Phase 2a PART B is complete.
Well the beautiful thing about ADAPTIVE Trials , which the FDA gave guidance upon and the Phase 3 TRIAL which the FDA is GIVING guidance upon..
it that they are..
ADAPTIVE..
At this point Anavex PLUS while still very important..is not
necessarily important at Anavex Monotherapy..
Anavex had no idea, that Aricept may work against the treatment by clearing out A2-73 and 144 before they are able to fully achieve affect..
We will have to ADAPT the Phase 3 Study so that EACH LINE may be a separate Pathway to approval..TauRx has 2 Separate Trials..the Mono Therapy Trial is still ongoing..Personally I think Anavex should review the Path of TAURX regarding two bites at the Mono-Therapy Apple..
With One Arm being Monotherapy in the next Phase 3, but a new and completely different study of JUST MONOTHERAPY..
Look with all the IND's of Anavex..
This will become the GREATEST CROSS PRESCRIBED DRUG IN THE HISTORY OF MANKIND!
PUMP YOU UP!
These guys are encouraged to write hack pieces for some reason by some person..so..my point is ..I certainly would not bring up the fact that
Anavex may be a most sublime treatment for INSOMNIA.a $32 BILLION ANNUAL MArket!
Oh My! Do you think THAT IS THE REASON we saw such activity after the Quarterly? A $32 BILLION ANNUAL Market would take little ol'Anavex
STRAIGHT TO THE MOON! where we could eat Havarti and drink Ambrosia..and
SLEEP! Real peaceful like..
Market for Insomnia $32 BILLION, Alzheimers' $10 BILLION, Depression..BBBILLION,
WOW..Let me tell you as story about Jed..He could not sleep at night..
until he took some A2-73..and then up from the ThREES came a bubbling Anavex..Dun nunt du dun dun dun..
The KINFOLK SHORTS said Jed Don't you dare! But sleep Jed did..and now
Jed's a Millionairre!
Does this OFFICIALLY MAKE ME A PUMPER?
What does it take?
Anavex NOW!
Don't be RENAUERED!
by January we should have full 52 Weeks and have started Phase 3..
the funny part is ..he mentions Insomnia like Anavex is making that a fall back position..aka , Nyquil..LIke Insomnai is a small market.Quick check on Insomani Market..
Hi sHANDLERS must be crying "IDIOT!"
Insomnia is a $31 BILLION ANNUAL MARKET..
That may be 3 TIMES ANNUAL Alzheimers Market..
IDIOT!
http://www.thefiscaltimes.com/Articles/2012/07/23/Sleepless-in-America-A-32-4-Billion-Business
New Seeking Alpha Article should raise your BULLISH Senses!
Somebody is scared witless..because they have written
an article sans..wit.
so likely to sell shares and try other indications like "INSOMNIA".
it is hilarious! It's like you waiting for Corey Renauer to give
you the punch line.
How many times must Anavex say Phase 3 for AD? or..
How about this one..a $2,000,000 burn versus..say AXON's $25,000,000 Quarterly Burn rate..
But really I think the best or worst is the OUTRIGHT LIE,
"clearly not a promising prospect for Alzheimer's"
TELL THAT TO THE MAGNIFICIENT 7 on MONOTHERAPY!
Does he think us ALL BLIND?
How can ANYONE say that and GET AWAY WITH IT?
LET's SUE! haha..heck no..Let's ACCUMULATE! haha..
The sweetest revenge..I smell fear
PUMP YOU UP!
Combined Depression(Anxiety IND), Alzheimers(Dementia IND), Insomnia, Epilepsy(Siezure IND) equals a Billion Dollar a Day Market..(IMO)..
We have the DRUG!
It's Sunday..thought everyone would enjoy some humor!
but really..I kinda mean it!
Efficacy argument for immediate availability of A2-73 for Mild to Moderate AD Patients:
Patients who have found the side effects of ARICEPT/Donexpipil Unacceptable should immediately be allowed (with some exceptions) to take A2-73..
Patients who are not experiencing any benefit to A2-73 should be allowed to
take A2-73 as MonoTherapy or in conjunction with DZP..
Patients with INSOMNIA and ALZHEIMERS should IMMEDIATELY be allowed to take A2-73!
Patients with INSOMNIA and DEMENTIA of ANY KIND should immediately be allowed to take A2-73..
Let's start HELPING PEOPLE..What the heck are we waiting for?
Licensing Partnership(No INvestigation) vs. Dilutionary Secondary Offering(little to no selling into Lincoln Park Equity Deal).
to fund a Phase 3 for a mulit-annual billion dollar business.
And the bag'o chips is 9 month Data(which we already have) will be served up..shortly..probably in a PR(eh?) ..9 months ended 7-22-16..
why that was almost 3 weeks ago...
selling the Co would be a disaster..Please don't do it good Dr.!
nice alliteration. well done.
thank you Benny!
Until the Shorts are NOT SUCCESSFUL..they will continue to try and attack
when over $200,000,000 MC..Scaring Retail is too easy above that number as retail is not used to a CEO having their back..they are so used to greedy CEO's that give their family Options for flushing the toilets..that they don't understand who the good Dr. is..It is understandable and it is hard knowing the pattern will most likely repeat..not trying to take advantage of it..Accumulate..They laugh..but I say it again .our venture is measured in B's not M's..Many , Many B's..
we are getting so much bang for the buck!
$2,000,000? are you kidding me? with Conference and
major midpoint of adaptive Phase 2a showing Safety and Efficacy(for Multiple IND!)
..If this were a BP at this point $2,000,000 would have been 10% of Funds spent last Quarter. (http://www.gurufocus.com/term/CashAndCashEquivalents/NYSE:AXON/Cash-And-Cash-Equivalents/Axovant-Sciences-Ltd ..forget BP just look at Axonvant's BURN .$20-$25 Million a QUARTER!..and that is not EVEN BP.but a similar Co. setting up and going through Phase 3..I think they started with like a BIllion..they have probably spent over $500,000,000 on a KNOWN loser!
OUR MARKET CAP IS NOT EVEN $200,000,000! And OUR DRUG WORKS!
Look at the cash burn AXON in Phase 3 with a proven LOSER for a drug..
They KNOW is't NOT GOING TO WORK.http://ir.net/news/stock-news/123517/axovant-sciences-ltd-axon-shares-plummet-on-pfizer-drug-trial-halt/)
(.and look at them BURN THROUGH THE CASH!
We are Blessed..A Partnership comes this way....
and I would not want to be the one trying to take
the good Dr.'s chips away without FAIR & JUST Reward.
Anavex and her SHareholders have EARNED everything coming
our way.
I think you are well low on the 100,000,000 but I would trade
lower dollars upfront for higher dollars / .% on Expense/License/Marketing deal...
ALL DAY LONG.
I just thought using "Steady" at this point for Anavex was funny..
long..short..man the only thing Anavex doesn't know how to do is steady..
this stock is Manic Depressive..it could use a Chaperone to make sure it gets better SLEEP, doesn't get too DEPRESSED on the bad days, and feels HAPPY to face the next challenge! '
Hmm..maybe we should all take some A2-73? I am ready Freddy!
A short and steady climb?
haha have you seen the chart? You want Alcoa or Coke..
a short and steady climb..that made my whole weekend..
This stock whould come with a pacemaker attached..
Another tidbit of info..
We all assumed that PART B would continue to be made public, but we also all realized after seeing 26 Week data that Anavex may keep Data until 52 Weeks was finished..
So..we found out that 9 MONTH Part B or 38 WEKKS Part B will be released.
Assuming Week 1 Nov 1
38 Weeks ended July 22nd..
We might be seeing 9 Month data..sooner than anyone thinks..
a lot sooner..
also keep in mind..Anavex already has much Data for Interim 52 Weeks..
Wonder what the Data looks like for the magnificient 7 on Mono-Therapy?
Wonder if they will keep that separate Data stream going?
Ya' Think?
good day for Anavex.
Interpreting some tea leaves..
- Financing Phase 3 from Secondary seems unlikely as does not appear Anavex raised any cash using Lincoln Park Deal. If ANYONE thought alterior motives at hand for Pre AAIC titling/PR to raise money..this was re-assuring..
SINCE not looking to raise money..It also means two other points are more likely..BP Licenisng Deal..+ NO major Dilution..(Skewers Market Maker Shorts waiting for secondary & lower price).
Also .I mentioned this earlier and it was emphasized again by the good Dr.
Insomnia in Alzheimers Patients and really accross the WORLD is a disaster with almost EVERY MEDICINE having HORRIFIC SIDE EFFECTS!
Either they are wickedly Addictive ro hallucinegi=ic or BOTH..Bad Stuff..
But for Alzheimers sufferers and their families and caregivers..the INSOMONIA TURNS EVERYONE INTO A DOGGONE ZOMBIE!
Someone posted doeing a down & dirty Insomnia Trial..AMEN!
honestly ..there are some deserving companies for Short Selling..but to destroy honest efforts for criminal gain..someone should go to jail..
Surely you jest? You mean "be dismissed" for lack of any reason for them being filed in the first place..or whatever..you don't mean "settled".
We have already determined this lawsuit to be a joke and without merit..
few shares , short cabal team member...NO ONE IS WORRIED ABOUT THAT Lawsuit..No One