Well, well well. Bioscience can not even create their own stupid reasons that Anavex is a failure, they simply regurgitate the ignorance of others.
First, let me just say, when a writer describes the Chess Match being waged by the good Dr against Big Pharma, as not being "run smart", you immediately realize the writer's lack of accomplishment at the one skill you would expect a modicum of proficiency, writing.
So it is a take back to spend any further time with the article, but for you, the Anavex believer, and our collective sense of trench warfare humor, i battled forward.
As feared, a complete and total waste of time. All they do is repeat fears of too much spent on G&A. I love Corey Renauer's suggestion that Anavex OWN IT'S OWN LAB! What an IDIOT! But at least Corey ignited his own idiocy, this guy can not even come up with one Short Bash of his own. If he did, I could not find it.
The other bash he brought up was the hit piece from the "Street" or SA that was just published, where they say Anavex doesn't work for AD, the Trial was too small, there was no placebo group, A2-73 only works for Insomnia, etc, etc, etc..
Man the "analysts" would do anything for a Placebo Control Group!
But Alzheimers doesn't neeed a placebo control group, because EVERY SINGLE DRUG GIVEN TO ALZHIEMRS PATIENTS HAS BEEN A PLACEBO CONTROL GROUP!
We KNOW what happens to Alzheimers patients GIVEN ANY DRUG, THEY DIE a miserable and rotten death! Control Placebo group well kiss my irish-hungarian heart, they just don't care.
We don't have to go over the FDA helping design and guide the Phase 2a, nor the fact that the FDA is helping guide the design of Anavex's Phase 3 for Alzheimers.
But I do want to point out some simple obvious points.
When Anavex decided to pool the Data, it meant that those patients who were not responsive at all, would be combined with those patients who did respond. (ALL PATIENTS CONTINUED ON THE DRUG FOR 2 YEAR EXTENSION!)
The non response numbers of a Placebo Group would have fallen 4-6 points over 6 month study, 7-9 Points over 9 months..It is a linear fall for Alzheimer's on two of these tests(ADCS-ADL and MMSE).
After 5 weeks in many previous tests with 1000,0s of Patients in a Placebo Blind Group-they generally all reacted the same- the Placebo Effect was almost nonexistent in previous studies, so any positive effects after 5 weeks are going to be from the PK of OUR DRUG, A2-73!
I don't want to go too deep into the Mono-Therapy data..but from 12 Weeks to 26 weeks after which these 7 patients would have been expected to register a 16-18 on their mmse(from 20) they registered a 24.
I don't know why the stock is going down. Wish it wasn't.
But I am a BIG BELIEVER not just A2-73 as a treatment for Insomnia, a $32 BILLION business, Depression, epilepsy, rett Syndrome, etc..on and on..
BUT I am a HUGE BELIEVER in Anavex as a Mono Therapy.
With the data pooled, and Phase 2a PART A and PART B being a SAFETY test with Efficacy secondaries..and using POOLED DATA..we must simply trust the good Dr. when he says the Combo Therapy shows promise.
Period.
Phase 3, ..Thank you very much.
And we can begin all the other Phase Studies..sooner rather than later please..
And I am for the Immediate Availability of A2-73 for ALL Alzheimer PATIENTS..If A2-73 is SAFE, WE DEMAND THE OPTION TO USE IT!
I should end with some sort of tie -in to the beginning regarding the poorly executed, non-creative hit piece by Bio-Science, but honestly, I am too excited about Anavex to relive the nightmare.
So go on with yourself..
AI
