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Yes Bigworld, there are a lot of new products in the pipelines headed for market. Unfortunately, our products don't seem to be able to get beyond the verbal stage. Instead of being a corporation that is at the forefront of the science and having a couple of products actually on the market, we are still trumpeting the fact that we have actually talked with the FDA about submitting an IND.
I suppose this should be expected from a corporation that has its finances riding on the bald head of someone who has absolutly no real world experience and at best can place small underpriced PPs thru a few people who may possess questionable credentials themselves.
It is also the result of having a CEO who possesses great academic credentials but has none insofar as the real business world is concerned. One of Malcolm's greatest liabilities may be thinking that we should not be a marketing company. We should just license our technology and let others do the dirty business of 'selling' a product. It's gonna be interesting balancing that with the DNA production facility.
I'd like to be able to answer your questions about the CYGX vs Waldroff suit. (Remember CYGX brought the suit and Waldroff just countered --- and won.) I could state a lot of speculation, but there is just absolutely NO good answer for it. If I repeated some of the BS Malcolm and Lawrence have said you would be rolling on the floor laughing, but still scratching your head.
Our problem is that we have one of the finest back-shops ever assembled. Remember Yin worked on this longer than anyone ... he was with Charlie Conrad before he came to CYGX in that mini-merger. He, Harrilyn, XXT and the others are the only real assets we have when it comes to personnel. They deserve a h&ll of a lot better than they have been provided.
Paul-NESS, you just joined the ranks of Jane Fonda. Your response is sick and demented. If this was an attempt at humor, you failed and did so in a most miserable manner. We were winning the war until those flower-chicks and people like the traitor Jane Fonda gave aid and comfort to the enemy. I lost one h&ll of a lot more friends after that than I had lost before.
I guess you are in that crowd that thinks we need to completely realign our American way of life in order not to anger those poor souls in Al Quaida who want to kill each and everyone of us.
I am glad we can visit Viet Nam today. I love the Vietnamese people ... and the Laotians, as well.
Well, the good news for you is that Hanoi Jane ( or is it Hussein Jane now) will be firing up a veggie powered bus and protesting the Iraq action. I just hope she and her type are not responsible for as many deaths in the Middle East as they were in the Far East.
Once again, the self proclaimed master prognosticators and gurus on this thread have shown their total lack of being in possession of any material facts.
CYGX appealed the verdict and it could be (see Paul-NESS, I forewarned you) that they are trying to avoid having the clock start on the court imposed deadline to deliver product. It might be that they can't deliver what they are obligated to deliver and that could be the reason they are spending another $70,000.00 of our funds to delay the inevitable.
AVGI could have been a God-send to CYGX. By now, large animal (equine) testing could have been completed and a product could have been brought to market thereby establishing a cash flow ... you know, the one some of the psycobabblers keep mumbling about being just around the corner.
I suppose a few of our regulars will want to go into attack mode over this post ... of course they KNOW absolutely nothing about the intrique that has accompanied this fiasco. And they have NO FIRST HAND information concerning the litigation that was spawned when CYGX decided to sue the first company they had licensed. Ignorance, of course, will not prevent their babbling on about that of which they know not.
Somebody call AVGI and ask them if they've received product.
They'd probably be more open to answering the question than Malcomb would.
Chad, I think almost all of us would like to see something positive on any front. The closest we get is the wonderful news that we are all going to benefit from giving away another 18 million stock options.
During the past year I have watched my holdings drop enough to have paid for an airplane, a new CTS and have been able to spend some good quality time in Fiji.
It's bad enough to have to count the losses, but then it becomes insulting to have to listen to a group of naive little kids chide us for not appreciating all the good that is being done for us.
Wonder if the Taiwanese still hold all of their stock and why they didn't follow thru on everything they were going to do a couple of years ago? Think we need to re-post some of those posts from that era?
Good Lord Paul-NESS, are you kidding? When has ANYTHING you have alluded to actually came to fruition? Where are all of those things you have coyly sugegsted were possible? That kind of reasoning reminds me of those stupid naive little girls running around saying that if we all wore a flower, the killing and suffering in Vietnam would cease.
Some of us may have just reached the point that the sound of Malcolm's or Lawrence's voice puts us on notice and on guard for another round of BS.
IF, IF, IF, MAYBE, MAYBE, MAYBE and then you follow it up with some nonsensical day-dream. Hey, what are the chances that your predictions and what-if's from years ago are going to actually become ARE's and IS's?
For starters, where are all those benefits from granting the second round of exhorbitant stock options?
If I see one more "what-if", maybe or could be from you, you can expect to see a reciprocal round from me ... and it will be just as valid as your optimistic prognostications have been. For example, what if a ton of the PPO's have been thru someone who was not licensed to make them?
If you listened to Malcolm, you can deduce when news will come out, and on what topic ,you just have to listen , but I think for some reason you are so mad at Malcolm, that you literally can't listen to his voice, maybe he irritates your bleeding ulcer, I don't know what it is, its your loss. If you didn't have a pessimistic attitude you would be much healthier.
What in the world is wrong with you Arnold? Is there any good reason for you to mention a normal scenario for the conduct of business? Is there any reason to start doing things normally now?
We have done alright with an inexperienced CFO, haven't we? Hasn't he raised all the money we need for research and development activities? Hasn't he been able to fund all of the needs with the use of greatly underpriced private placements?
Hasn't our CEO been able to do well without experience? Although he is no doubt well educated in IP matters, is there any reason that he should have private business experience outside the academic arena? Remember, we're getting ready for IND's this year ... or is it pre-IND's?
Come on Arnold, why do you keep harping on the need for experience and additional funding? Now it looks like we're going to have to sit around and listen to you chirp about experience in manufacturing ... please tell me it isn't so.
And get off that "why no buyers for licenses." CYGX has already gained experience in issuing two licenses ... well, current management has issued one license. Don't try to make fun of the fact that they both ended up in law suits and CYGX got creamed when they sued over the first license. The important aspect of this is that CYGX has indeed been successful in getting deals on TWO licenses. OKAY?
Very strange after yesterdays movement. Equally strange is the lack of postings concerning the SHM. If it was good, you would expect the usual rah-rah gang to be jumping up and down. If it was bad, you would expect to see a drop in share price.
Tatankano, I just re-read the chart you posted. On closer examination, they say that the big block that moved at 1559:39 was @ .515 and that the block of 10,500 which moved at 1558:09 was for .55. All of this transpired when the posted BA was .46 X .50. However, it is obvious that someone put in a bid at .55 for the transaction at 1558:09.
No matter how you cut it, that is a big hunk of change.
I think I've only missed one meeting since we got this started. Actually I had proxys and powers of attorney, but I didn't think to stick them in my briefcase ... duhhhhhhhh ... oh well.
Just for everyones information, I was denied entry to todays shareholder meeting. I was told that stock held in my wife's and son's names did not count as none of it was in my name on the cutoff date of 14 June 2005. Three days later 100K shares were transfered into our joint account, but apparently that does not count. LOLOLOL
Well, I'll join the crowd wondering what happened.
Paulness, my Level II's show a transaction of 10,500 shares at $ 0.55 with 14 seconds remaining until the market closed. At the time, the bid was $ .46 and the ask was $ .50. Now, who is playing games when the sale is for 10% about the ask? hmmmmmmmmm
Good grief ... Hogger was in the court room. gdepc wasn't.Hogger has been contacted by just about everyone on the planet that has an axe to grind with CYGX and any of the management group. gdepc hasn't. Hogger still owns stock in CYGX and so does his family. (Albeit not as much as we once did.) Hogger wants CYGX to succeed beyond even your wildest dreams. Problem is that the current team appears to not be getting the total job done. And this latest show of greed is just too much.
how would hogger know
Unless they do it differently from past years, the vote will be announced at the meeting. The meeting is at 2:00PM (1400 c).
Are you going? Want to meet at the coffee shop on the right hand side as you come in the entrance? What will you be wearing?
hogger
are you going to the shm
gdepc
Surely you jest.
EC, long, long time, amigo. What have you been up to? Things are just pretty much the same around here. Scoob and Paulness still pumping out the company line that Marble-Top Lawrence feeds them. Seems he just didn't have the time to continue trying the hair restorer, so after many months, he just quit. Of course with some of the developments lately, he was probably going to have any new hair fall out anyway.
Anyone questioning anything is branded a basher ... or worse.
Management wants to give itself another 18 million shares in options so they can dilute the equity we hold by another 15%. Since they put out that idea, price has dropped a good $.20. Of course, some say that is a good sign because it proves that management knows something the rest of us don't.
CYGX sued Bill Waldroff and AVGI and lost. (Actually, they got their butts kicked pretty badly.) Lots of very interesting testimony came out in the proceedings. Some of it is still under consideration and investigation. Shareholder meeting tomorrow offers the posiiblity of a lot of fireworks.
A couple of us have been busting out rear ends to reduce the amount of shrapnel that could fly, but won't know how well we have done until the gavel drops to end it.
Anyway, hope to see you back with us. Good luck ... and wish us the same.
Well, if you want to really feel bad, ADD the 15% share option giveaway to the current drop and we're in the 40's.
This is shaping up to be the most contested shareholder meeting yet. There may be all sorts of surprises.
Management has to shoulder the total blame for this drop. They could have avoided it and kept harmony in the ranks by just dropping the select-few giveaway from the proposals to be voted on. Ahhhh, anyway, they may well get their additional stock options ... the fact that we shareholders have lost over $20,000,000 in the past days doesn't matter.
Sic transit gloria mundi.
All that matter is the close.
CYGX: CYTOGENIX INC - 7/13/2005 4:43:53 PM ET
Price___*Change*____% ChangeBid__[tick]____Ask
0.54_____-0.05_______-8.47%0.53___ [+]_____0.55
B/A Size____Open______Volume
25 x 25_____0.59_______360,780
* Calculations (Change and % Change) based on previous day's close
I imagine he was out-gunned ... lol. Anyway, he became one of the best negotiators our international union had. He walked into a negotiating session that had been deadlocked. When he removed his top coat, he was wearing nothing except a jock underneath. Well, he did have a sign around his neck that said, "Strike."
There are some folks that you just never know what they will do. Presidents Kennedy and Reagan (and to a degree, both Bushes) were that way. They made some pretty wild threats, but of course, they were always prepared to take the action they had threatened.
I guess any one of the bikers could have tried to fight back, but they might have gone down in the process. BTW, the 'gang' went over and policed the yard and helped replant the flowers and shrubs that had been destroyed. I think the Mom ended up providing them with cake or cookies. It is amazing what can happen when everyone does the 'right thing.'
... Well Happy, for the past couple of hours I've been hearing about the explosions that created that smoke. Some folks are just perfect examples of wild and crazy guys ... LOL
Reminds me of an incident with an acquaintence a few years ago. Seems some bikers had been giving his Mom some problems and ran their bikes thru her yard. So, he arms himself with a few weapons and strides right into their hangout - a bar in a mid-Western city.
He kicks in the front door just as they have assembled to toast their leader. He fires a couple of shots and announces, "Fellows, I'm here to die, but before I do and take a few of you with me, I'd like to sit down and talk."
To make the long story short, they all get rational and he is accepted as a peer and his Mom was never bothered again. Now, that is a wild and crazy guy.
I see more smoke down in Chimneyville Hogger. Things just don't add up.
Hey Texguy, was your swami formerly with Bottompicks?
There is a rumor that some folks are very interested in Bottompicks. Any idea why they would be a concern to anyone these days?
gdepc, ni-how, anyong haseo or kinechiwah (not sure which),
Why don't you re-read Arnolds post? I think it should be very easy to understand.
arnold you are saying cygx is running a scam with there
Cytogenix DNA vaccine
possibly not even in existence
Now, how about you sitting down, thinking this thru and rebutting the posts questioning whether or not the vaccine actually exists or is in development. Big difference.
I have also been informed that the revocation message can be sent via e-mail. It should be addressed to Lawrence Wunderlich via the CYGX email. Contact info is on the website. It was also suggested that the message be CC'd to someone you trust or to your alternate email address in case there are any questions concerning whether or not it was sent. That is in the event that the measure passes and is subject to further legal action.
If anyone has voted or given their proxy, there is still time to revoke it. Here is what I previously posted:
For anyshareholders who have already given their proxy and wish they had not, you can revoke the proxy or vote. Here is a copy of a post I made on Ihub and RB ...
I've consulted with our legal beagle and he suggested the following:
To: Mr. Lawrence Wunderlich, Secretary, Cytogenix, Inc
Re: Proxy for 2005 Shareholders Meeting
Sir,
I hereby withdraw and revoke my previously issued proxy. I instruct you to NOT use said previously issued proxy in any manner, including but not limited to, determining a quorum of any manner.
Sincerely,
(Your name, signature and date)
Send that to:
CYTOGENIX, INC.
3100 WILCREST, SUITE 140
HOUSTON, TEXAS 77042
It will be best to send it via USPO Certified or Registered mail, return receipt requested.
Well Paulness, according to the PR, ... here ... read it again for yourself:
Dr. Malcolm Skolnick, CytoGenix President and CEO commented, "We believe that there is an opportunity to develop a smallpox DNA vaccine that will be safer and more effective than the live cowpox vaccine currently available. This important scientific collaboration with Dr. Weiner, a pioneer in this field, demonstrates our strong commitment to advancing DNA vaccine technology to the forefront of clinical use."
After all these years of reading CYGX PR's, it is apparent that you need to really read them carefully and determine what they actually say instead of scanning them and believing they say what you want them to say.
Now, you show us where it says the product has been developed. Oh, and where does it say that the testing has begun.
However ... good try.
Scooby, please, please post a link or at least an explanation of this:
It amazes me that old foe's of CYGX's current management still after all this time haunt them. They have never gone away, just changed aliases. They were ordered to stop by the courts but they have family and friends carrying the torch.
If you can substantiate this, I may well be able to shut a couple of them down. If you are uncomfortable posting this in the general forum, then please, pelase send it to me thru the "cygxproxy@sbcglobal.net" address. If you are uncomfortable with that, then please, please send it via a third party.
This is a most important matter and could greatly influence pending litigation that is actually beneficial to CYGX.
Bakatcha ..... g'nite ..... now, look into my eyes ... you are getting sleepy ... your eyelids are feeling heavy ... ROFL ... I must spend too much time in either Shanghai or Seoul ...
Why don't you do the same thing you did last night? ROFLMAO
He was my stockbroker, as a matter of fact. Of course, I was "IN" CYGX before I knew who he was. I believe that his extensive experience in that position qualified him for the position of CFO.
Question: Wasn't LW a stockbroker before his current position with CYGX?
TIA
CD_98
You should hear the results of the phone call I just got ...
Great idea ... think I'll find the Scapa ... lol.
I'm enjoying the rants and raves ... you should hear the ones that I just had on the telephone .... don't you hate it when all you get is an answering service ... lol
It's lonesome in the great Southwest ... even at this time of the evening.
I hate to be petit, but didn't I post that and Paulness responded? Anyway, thanks for posting it again, we all agree on the importance of the scientists at CYGX. Wonder what they could accomplish with proper funding from their CFO and alliances negotiated by their CEO? BTW, glad Dennis is missing you.
http://www.investorshub.com/boards/read_msg.asp?message_id=6904387
gdepc, this is total BS and you know it ...
I hope you and your anti cygx group did not spent to much money on your legal beagles
Of the entire group who have responded to the option giveaway, not a single one of them has given any indication that they are anti-CYGX.
Most of us have been in this stock for years and some of us have been intimately involved. We consider Yin, Harilyn and their team to be the epitome of genius.
Our problems have to do with this outright show of greed and the misinformation and lack of information provided to those of us who have financed the operations.
Is your Lawrence Wunderlich the same chrome domed (and yes I'm also a marble-top) who once touted the hair restoring powers of our technology and even had a little framed prescription on the wall of his office for a compounding pharmacist to use our technology? Well, has LW grown a full head of hair?
Although we have reduced our holdings as a result of this latest greed inspired equity option grab, we remain shareholders and would like to see the value go up, up, up.
If there is anything to the stories I am hearing from the Deep South, getting a quorum may very well be the very least of managements problems.
gdepc, I think you already know, but in any case, I'm not going to say anything further at this time. There may be a far more important forum in which to discuss the matter.
If you need an answer right this moment, you should ask CYGX management ... oh well, I've got to run ... got a Great Danish meal to devour ...
Well, the young lady at Morrow finally called to solicit my proxy. She was very nice and didn't hear anything from me that she had not heard from others.
I explained the reason that so many folks are declining to return their proxy or to vote in any manner and she understood. However, as her job requires, she suggested that if we are opposed, we should vote against the proposition.
After I again explained that withholding (or revoking if already granted) our proxy was more effective, she did agree that without a quorum the propositions could not pass.
gdepc, you are absolutely positively 100% correct ...
there is a lot going on that we all don't know about
Conspicuous by their absence are some very interesting facts that 'they' obviously do not want us to know about. Any guesses as to what this really means ...
Negotiations are being conducted to obtain the rights to use a further identified alternative backbone in combination with the sequences we have discovered and found successful.
Here is the release by Jennifer ...
Valued Shareholders:
We would like to profile the Company progress over the 2nd calendar quarter of this year. We continue to make scientific progress as demonstrated by our scientists’ published papers in respected scientific journals. As a matter of maintaining scientific integrity, papers in scientific journals are reviewed and approved for publication by committees of independent scientists. This is tangible evidence that the Company’s research is highly relevant.
Publications and Scientific Meetings:
1. Tan, X., Actor, J.K., & CHEN. Y., PNA Antisense Oligomer as a Therapeutic Strategy against Bacterial Infection: Proof of Principle Using Mouse Intraperitoneal Infection Antimicrobial Agent and Chemotherapy, (accepted for publication), 2005.
2. Tan, X. & CHEN, Y., A novel genomic approach identifies bacterial DNA-dependent RNA polymerase as the target of an antibacterial oligodeoxynucleotide, RBL-1 Biochemistry, 44:6708-6714, 2005.
3. Tan, X., Knesha, R., Margolin, W. & CHEN, Y. DNA enzyme generated by a novel single-stranded DNA expression vector inhibits expression of the essential bacterial cell division gene ftsZ, Biochemistry, 43:1111-1117, 2004.
4. CHEN, Y., Tan, X., and McMicken, H. “In vivo generation of oligodeoxynucleotides for regulating gene expression”. Keystone Symposia, New Advances in Drug Discovery, March 21-26, 2004, Keystone, Colorado.
5. CHEN, Y. “A Novel Single-Stranded DNA Expression Vector”. Louisiana at the Crossroads:
Moving Biotechnology from Research to Commercialization, Shreveport, LA, June 24, 2004 (invited speaker).
Sponsored Research Agreements/Collaborations
Sponsored and collaborative research are very effective and economical methods of employing top-notch scientific talent and expensive facilities for a fraction of the cost if we were to replicate these efforts in-house. Sponsored research is paid for by the Company. In collaborative research, one party may provide technology and the collaborating party may use the technology in an investigation. The following is a summary of sponsored and collaborative research projects in progress. The fees charged by the institutions total less than $150,000.
1) Dr. Cy Stein (Albert Einstein Medical School/Montefiore Medical Center) has constructed melanoma stable cell lines with significant reduction of apoptotic gene, Bcl-2, expression at both mRNA and protein levels. The biological analysis of these cell lines has been completed. The next step will be to conduct in vivo (animal) experiments to study the effects of CytoGenix antisense clones on cancers transplanted into mice. Louisiana State University Health Science Center
2) Dr. Frank Orson (Baylor College of Medicine) is currently conducting an in vivo study to use aerosol delivery of the ssDNA expression vector targeting pKC-alpha, an oncogene associated with lung cancer. Several variations in delivery methods are being tested including polyethylenimine (PEI) with plasmid IP, naked plasmid ID and PEI aerosol.
3) Dr. Michael Mathis (Louisiana State University Health Science Center) is currently constructing single-stranded DNA adenoviral expression vector.. He is planning to use this vector to target eIF4E in head and neck cancer therapy.
4) Drs. Edward Mason and Jesus Vallejo (Texas Children Hospital, Baylor College of Medicine) are investigating Peptide Nucleic Acid compounds as therapeutics for bacterial resistant strains such as Methicillin resistant Staphylococcus Aureus (MRSA) and Vancomycin resistant Staph (VRSA) using a mouse model.
5) Dr. David Weiner (University of Pennsylvania Medical School) is conducting animal studies using Cytogenix’ synthetic DNA to test the immunological activity of a DNA vaccine against small pox.
6) Under Agreement, the Company has provided synthetic DNA to test the immunological activity of a DNA vaccine against Hepatitis B.
7) Under Agreement, the Company has provided synthetic DNA to test the immunological activity of a DNA vaccine against Flu.
8) The Company licensed a compound from the National Institutes of Health (NIH) to prepare a synthetic DNA construct to test a DNA vaccine against HIV.
9) Dr. Jeffrey Actor (University of Texas Health Science Center-Houston). has completed a study investigating peptide nucleic acid (PNA) antisense oligomers as therapeutic agents against bacterial infection in a mouse peritonitis model. The PNA treatment was sufficient to rescue up to 100% of the bacterial infected animals. This work will be published in the journal of Antimicrobial Agent and Chemotherapy in October of 2005.
10) Negotiations are being conducted for sponsored research on mechanistic studies to demonstrate proof of biologic activity of the anti-inflammatory compound (CY303)
Product Development:
1) Herpes/Simplivir: primary vendors and back-ups have been identified, experimental protocols defined and budgets prepared for studies needed to complete the IND application to the FDA. These include:
* Bio-distribution studies ;
* GLP Toxicology;
* DNA drug substance determination; and
* SIMPLIVIR drug product.
Vendor selection and project initiation await funding.
2) Anti-microbials: We have tested two anti-microbial compounds against gene targets; one in Escherichia Coli and the other in Staphylococcus Aureus. These compounds were made using different chemical backbones than the usual sugar molecules in standard DNA. The backbone is the structure used to support the oligonucleotide sequence designed to down-regulate a particular gene target.
Thirteen (13) additional gene targets in Methicillin resistant Staphylococcus (MRSA) have been identified using the Company’s screening technology. The oligos against these targets are being tested in our laboratory. Sequences showing anti-microbial activity will be tested in animals at Texas Children’s.
Negotiations are being conducted to obtain the rights to use a further identified alternative backbone in combination with the sequences we have discovered and found successful.
3) (SynDNA) Facility: Alfa Laval Biokinetics has completed a feasibility study for design and construction of the facility. The feasibility study includes timeline and cost estimates. The Phase I Engineering Study has also been completed.
Intellectual Property:
New U.S. patent application, “Cell Free Biosynthesis of High-Quality Nucleic Acid and Uses Thereof”
New U.S. Continuation-in Part (CIP) application to strengthen enablement combining:
“In Vivo ssDNA Expression Vectors” together with
“Identification of Novel Anti-Bacteria Agents by Screening the Single-
stranded DNA Expression Library” and
“Nucleotides for Prevention and Treatment of Bacterial and Fungal Pathologies”
National Filings in eight (8) countries under the Patent Cooperation Treaty (PCT) of the U.S. patent application, “Treatment of HSV-Related Pathologies Using ssDNA”
We look forward to continuing this work and appreciate your continuing support.
Very truly yours,
Malcolm Skolnick
HC, do you actually know any of the people involved in management? How many times have you sat down and shared a cup of coffee with them? How often have you discussed the technology and the various strategies? How many time have you offered your opinion on various matters to them? How many times have you been told information that ... uh, shall we say ... eventually didn't prove out?
I'm sorry, but your approach and interpretation of this entire matter seems ... well, more than a little utopian.
In the instant matter, we have a scenario that can be resolved in several different ways. This could have been laid to rest and we could be concentrating on other matters if management would have just chosen to show patience and placed shareholders interests above their own greed. But, once again, they chose to take a hard headed approach that is leading to a lot of disagreement from the shareholders. Remember, this is not a family business that belongs to a few individuals. This is a publicly owned corporation and you and I are no less owners than any member of management, albeit we hold less stock.
And just for the record, there are other forums in which to address this and their ramifications far exceed anything we might say on these internet stock threads.
I've consulted with our legal beagle and he suggested the following:
To: Mr. Lawrence Wunderlich, Secretary, Cytogenix, Inc
Re: Proxy for 2005 Shareholders Meeting
Sir,
I hereby withdraw and revoke my previously issued proxy. I instruct you to NOT use said previously issued proxy in any manner, including but not limited to, determining a quorum of any manner.
Sincerely,
(Your name, signature and date)
Send that to:
CYTOGENIX, INC.
3100 WILCREST, SUITE 140
HOUSTON, TEXAS 77042
It will be best to send it via USPO Certified or Registered mail, return receipt requested.