Replies to post #176014 on Biotech Values

[iwfal]

EXEL

By 0.75 You are assuming an overall alpha of 0.05. One can't rule oout 0.01 is being used instead.

Yes, I am 'assuming' that the total alpha is 0.05. If the total alpha were only 0.01 then I would agree the interim threshold would be about HR=0.72.

BUT(!) we know the total alpha is, in fact, 0.05 or close enough.

So I'll stick with my original assertion, thanks.