I have been following/posting on biotech boards for over 15 years, mostly on SI. My most posts had to do with Sepracor (SEPR). Eventually I had a large position and got to know management through going to annual meetings and putting up a fuss about directors' ownership and management options. Eventually worked out OK with sale of company.
I mentioned it just to emphasize that I have a large position for me. I have one larger position dating to late '70s in PGR with basis less than ,10/sh.