Look at no further than the Hapsburgs to see the effects of hundreds of years of in breeding... It caused all kinds of genetic anomalies including "insanity," seizures and the famed "Hapsburg chin," a severe jaw deformity... Some of them were absolute "freaks." And so goes the Holy Roman Empire, I suppose.. Do you think it's different when Arab cousins {or any cousins} marry, generation after generation?... Geneticists are still studying that Austrian jaw...
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