Well if the Jak's are multi-billion dollar drugs, then imetelstat has a lot of room in this space (if indeed they are complimentary).
I believe I have heard GERN CEO in the past say that no other drugs can alleviate symptoms (AND) hit the underlying cause of the disease --- which I believe he was hinting at -- imetelstat hitting both of those.
Guaranteed more color coming on this on the poster at ASH - however, this is clearly an active drug and potentially disruptive.