Is it not true a stroke patient always gets a cartoid doppler for stenosis, holter for afib, and echo for vegetative valve? Amaurosis fugax is an example where arthero emboli is generated from arthersclerotic carotid arteries obstructing the rential vessels. Artherosclerosis makes the vessel prone to damage and insitu thrombosis. Accelerated artheroscleoriss explains the increased in MI event, peripheral vascular disease, and stroke pretty well in ponatinib treated patients.