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oc631

07/11/13 8:22 PM

#163883 RE: mcbio #163881

[GILD] Enrolling GT1 patients in the Sofo/Riba study is bizarre. You don't drop clean, synergistic drugs like [GS-5885] you add them. You don't seek out longer durations with less potent combinations. Why not longer durations of Sofo/5885 in GT1? Why not study GT2 patients? Couldn't longer durations in GT2 help boost SVR rates within this genotype?










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jq1234

07/11/13 8:57 PM

#163886 RE: mcbio #163881

Not saying I think that is likely, but if you deny that's not at least some possibility, I think you're being naïve



Everything is possible. As of naive, well, if you think GILD would insert portion of a trial, which is so important to them that potentially threatens their HCV franchise which is why I used the word "doomed", into a ph3b trial that is conducted entirely in Russian, then you don't understand how biotech/pharma companies like GILD make decisions.

GILD certainly could have problem with sofosbuvir/5885 combo down the road. This isn't the clue they are sending.