Replies to post #28309 on Ariad Pharmaceuticals Inc fka ARIA

[lax20m]

Where is this info from?

[Maciste]

Please where is this information coming from??

[ariadndndough]

the info monday posted is from elliot favus what i been saying.

REMEMBER THESE WERE 3-4 LINE PATIENTS VERY SICK NO WAY YOU CAN COMPARE THIS TO FRONTLINE.

[Whosetosay]

Wow, this is significantly inconsistent with the FDA findings and the long term Phase I results. Without attribution, it is garbage. Not one one of the leading CML docs have said anything about this. And the Rx numbers don't support it.

It reads as if Pfizer wrote it. Who did? Where did you find this?

I notice you are very new to the board, welcome.

[Whosetosay]

The more I read this report alleged to be from Flavus, the more nonsense I see in it. It makes more and more sense it came from a Novartis or Pfizer backed source.

Suppose for a moment the information is accurate, though it is obviously anecdotal trash. Then:

1. The 10 patients that dropped out, where did they come from in the pool of 77, the 39, or the new 38 patients who somehow were not in, or refused entry into the trials. I suggest these drop outs could not be helped, even by pona. There is no indication they have been/will be put on Bosulif or any other drug, or that those drugs had been used and were not helpful.

2. Side effects from where, the FDA label? or the patients, or from every other TKI SE info on the market?

3. Treatable, nothing new.

4. Few consider Bosulif the better drug. The IMS data backs this over 6 months of Bosulif data.

5. So what. Nothing illegal. Sounds like Novartis, and BM and PF are getting really scared about market share.

6. Refutes and defeats the claims made in item 4. Illogical.

7. Long way from any real conclusions on this. BTW, Gleevec data shows recent drop in use.

View: The prescription data show the opposite. SE are common to all TKIs, and possibly less so with Pona in that it is intended for use for those that cannot tolerate other TKIs.

[AmpleKind]

FRAUD!!!!!!

The "report" from Monday1/Flavus reeks of malevolent fraudsterism! The tone is totally unprofessional, negative in all its "conclusions" and obviously has an agenda. This should get some attention from Ariad's legal department!


I've followed this board for quite a while, and I'm very happy that BTH is back (along with his fans iandy, and piece of). I have been hoping that we're going to go down for weeks, so that BTH will return with loads of "facts" and a good kick in the teeth of those exuberant, gogo, booster type "idiots" (yes, IDIOTS!!, if they're adjudged to be so by BTH then they are, and I join BTH in LOL,LOL).

So, there we are, with a good set of FACTS!!!! from BTH to explain what is happening (and he knew this was going to happen, that's why he got out at the best possible price point, $14, and he made a lot of money (we know that, he told us so!). Why should he have waited till $25?!!!

Anyway, vidpok, dough, all of you "know what you own" types, forget all this b.s. about pona from the likes of Dr.Cortez, forget that it's best in class, very likely a blockbuster (BTH fact: do not anticipate future prospects, the value of a biotech is what it is today, you just cannot know where we're headed, THAT'S a FACT!!!).

KNOW WHAT YOU OWN???? Hah, what you own is down, that's what you own! Future prospects? that's the future, who knows the future? The only thing to look at is the CURRENT price!!! Got that?

Lastly, I"d like to thank BTH for all those LOLs, and "idiots", etc.. Just remember, it's for your own good (and yes he's a bit rough around the edges, but he's as lovable a big jolly Santa Clause) and I especially want to thank him on behalf of iandy and "piece of", who crave BTH's facts(!!!) to keep from getting too optimistic about Ariad's prospects (they really do seem to crave BTH's facts). We need a counter weight to vidpok's crazed optimism (yes adreamer, do go into the closet, we'll come out when BTH is gone again, a sure signal that we're on our way up)

BTW, BTH, could you please let us know about the short term fluctuations in Ariad's pps, BEFORE it goes down. Post facto "analysis" is worth about as much as we paid for it.

[jochenVt]

Let's take a step back and try to see if this "report" can at all be accurate:

77 patients included in the analysis
If he happened to stumble over exactly the first 77 patients that filled Iclusig prescriptions, then the 77th patient would have gotten his/her drug in calendar-week 5 (3, 10, 18, etc.), maybe in calendar-week 4 (if we include low capture-rate in the assumption).
So the 77th patient went to the pharmacy sometime late January/early February at the very earliest.
Not sure if the drug is available immediately everywhere. I would assume some shipping-time from the "specialty pharmacy". So probably patient received drug 1-3 days later and started his/her regimen.
Doctors are probably asking for frequent follow-up visits in the beginning, let's say every 2 weeks or so.
Since the "report" was published end of March, supposed phone-interviews with doctors must have taken place a few days earlier (I don't assume that all doctors were available over the Easter weekend.) Interviews probably happened - if they happened at all - March 25th - 28th at the latest.
The patients must have had their latest follow-up earlier, maybe up to two weeks earlier. Let's be conservative and say all patients where seen by their doctors on March 20th or later.
This still means that patient No 77 had only 6 weeks on the drug (best case, realistically much less) and - supposedly - already a pretty good chance to have had a stroke, a heart-attack, perforated intestines and/or a ruined liver (non-reversible; the doctor managed to conclude non-reversibility all in 6 weeks or less from start of drug use!)
Pretty remarkable efficiency!!

Is this reasonable? You make up your own mind.