Replies to post #158714 on Biotech Values

[jessellivermore]

"This makes perfect sense as a threshold effect of observation".

God love you Dew...you are creative..

The ptosis is thought by some experts to result from action not on the lid levator, but on the frontalis muscle..on individuals who depend on frontalis action to clear the visual fields..These individuals may have underlying unrecognized ptosis prior to Botox. Ptosis which is masked by the frontalis action..The Botox is injected directly into the frontalis perhaps a little too low..Its really not clear why the ptosis clears so rapidly, it could have something to do with effort..

Love and Kisses....I will buy you a coffee at Starbucks this spring...Promise....":>) JL

[biomaven0]

Here's botox used to create ptosis - note the very wide range of duration of efficacy here:

Clin Experiment Ophthalmol. 2001 Dec;29(6):394-9.
An evaluation of the safety and efficacy of botulinum toxin type A (BOTOX) when used to produce a protective ptosis.
Ellis MF, Daniell M.
Source
St Vincents Hospital, Fitzroy, Victoria, Australia. [e-mail]
Abstract
PURPOSE:
To evaluate the safety and efficacy of botulinum toxin type A (BOTOX, Allergan) when used to produce a protective ptosis in patients where a surgical tarsorrhaphy would otherwise be required.

METHODS:
A total of 21 patients entered into the study. Doses of 2.5 and 5.0 units of BOTOX were injected into the levator palpebrae superioris muscle through the eyelid. The patients were followed daily where practical until a ptosis developed and then monitored 1-2 weekly until the ptosis was resolved. Injections were repeated, if necessary until the underlying condition had healed.

RESULTS:
Ptosis took an average +/- SE of 4.0 +/- 0.5 days to develop (range 2-8 days). Duration of ptosis was an average +/- SE of 46.0 +/- 12.1 days (range 1-206 days). The effective dosage was 5 units of BOTOX in 0.1 mL. In 16 patients, the ptosis produced by BOTOX was sufficient to allow the underlying disease to heal and a surgical tarsorrhaphy was avoided.