Replies to post #154111 on Biotech Values

[iwfal]

This is extremely interesting, and exposes the slow insufficient pace of discoveries centering around expressing a clear theory of cancer cell signaling

This is true in most of medicine - there is no comprehensive understanding of the architecture of a disease. And suprising little attempt to create one. E.g. T2D and the coag system are very good examples of systems where the global understanding is mostly large numbers of details with a few simple connection diagrams. And as a good way to understand that other methodologies are possible see immunology texts from 20 years ago - LOTS of stuff wasn't understood (comparing my 2010 edition of Janeway vs 1990 edition is an amazing difference), but the framework architecture provided great context even in 1990.

Part of this may just be due the complexity or tractibility (e.g. ease of running tests) - but the immune system is pretty darn complex and yet still managed to create an architecture framework very early. So I speculate that there is another factor as well. Science tends to reward specialization.