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iwfal

11/03/12 5:01 PM

#151708 RE: DewDiligence #151694

Today’s NYT article on Pradaxa is a textbook case of bias stemming from asymmetric information:



Given that there is indisputably one real meaningful problem and a second highly probable problem I would suggest it isn't very textbook. This is not to say that the problem you mention isn't real in the sense that it will exaggerate the SAE.
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biopearl

11/04/12 11:49 AM

#151716 RE: DewDiligence #151694

Dew, partially true. With coumadin the options of Vit K and fresh frozen plasma remain viable treatment options to reverse adverse bleeding. With Pradaxa the only treatment option so far is "tincture of time" (and a drug with a much shorter half life.) What really is important is what you don't see and that is a substantial reduction in thromboembolic events. Regards, bp