NFT formation and load correlate with cognitive decline and progression of AD and tau aggregates are believed to cause toxicity to neurons plus Wischik showed some very promising results for Rember in slowing disease progression in phase II, but data was not without weakness and Wischik didn't published a lot of data and somehow I get the feeling he only presents what he wants. So if the effect Wischik showed was real - I don't know, but if it holds up then the headlines he made since 2008 are not at all presumptuous.
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