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jq1234

08/14/12 7:45 PM

#147083 RE: mcbio #147082

for pain patients resistant to NSAIDs and who don't tolerate opioids.



That's not the trial ARRY797 just finished. The trial enrolled patients with OA of knee who had used NSAIDs before the trial and continued to use NSAIDs during the trial.
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biomaven0

08/14/12 9:15 PM

#147091 RE: mcbio #147082

The article you linked to referenced the failure of p38 inhibitors in RA.



Read the article again, looking at all the safety issues that were mentioned. Any of those would be enough to kill the drug in this indication too.

Peter