No, JQ's pointing out that ALS-2200 is a pyridimine, not a purine. ALS-2158 is a purine.
Right, I understand that. The point remains that one of VRTX's nukes is a purine and purines have a lot of safety questions now, thus necessitating the likelihood that VRTX likely won't be able to rely on just an in-house nuke combo.