Replies to post #146549 on Biotech Values

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Nucleoside/nucleotide drugs tend to have safety issues. If they didn’t, every company would have one that works well. Efficacy as a polymerase (or reverse-transcriptase) chain blocker is relatively easy to engineer, and these compounds are among the simplest small-molecule drugs.

A Systematic Review of Side Effects of Nucleoside and Nucleotide Drugs Used for Treatment of Chronic Hepatitis B

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2861763/