Data are good in general, but note that most data are for refractory/intolerant patients, who are not "real" refractory ones, rather they are refractory or intolerant. Intolerant patients tend to have better response rates plus they might still have other treatment option. The only data for patients "Refractory to all approved tx" come from a 44 patients group with ORR=20.5 so very few responders.