Replies to post #140886 on Biotech Values

[genisi]

This observation was known from the post-treatment phase of ROCKET-AF and is reflected in the new Xarelto label that includes a black box warning about discontinuation and explanations (in the guide) on the need to consult a doc before discontinuing the drug plus instructions on switching and transitioning:

http://www.xareltohcp.com/sites/default/files/pdf/xarelto_0.pdf#zoom=100

Also note that the big difference Piccini et. al. talk about was at the end of the study when blinded transition to open label warfarin occurred, probably because patients were insufficiently converted to warfarin i.e without proper bridging of anticoagulation coverage during the transition to a therapeutic INR.

[Superfly15]

Switching AF patients from Xarelto to warfarin in midstream is apparently a bad idea

Didn't you hear? Clotamin (SNPK) already completely pushed warfarin off the market ;-)