why are most of the patients enrolled to date near the lower bound of this range?
Because the current standard of diagnosis is to have a colonoscopy performed around the age of 50, and the manyfold who have had this procedure performed or a repeat of it (if colon cancer runs in the family) would not be interested in enrolling.
Because the exclusion criteria for the trial eliminate many patients who are older. Specifically a patient cannot enroll in the trial if they have had a colonoscopy in the prior 9 years or if they have had colon cancer.