The mechanism for life extension...
The mechanisn for life extension..by caloric restriction has shown to possibly double lifespan in some experiments and has shown in Bonobos to not only extend life, but to extend the period we consider youth.
Just to up date you...Scientists Tracy Keller and Malcolm Whitcolm at Harvard Med..have been studying and published in 2009 in Science the mechanism called the Amino Acid Starvation Pathway..
It turns out that in addition to the amino acids being the "building blocks" of proteins, they have another role in influencing some very basic physiological systems...So that the levels of certain AAs in this case proline and leucine effect the differentiation of naive T-cells into either T-Regs or Th-17s
This represents a major systems control of the inflammatory and "auto" immune systems..The scarcity of these AAs leads to increased differentiation into T-regs which supress the inflamatory and auto immune systems vs the Th-17s which stimulate them...Since a huge portion of the aging picture seems to revolve around inflamation and probably to a lesser degree auto immunity..The thinking is this supression is what causes the anti aging.
So it is not really calorie restriction, but the restriction of specific AAs.The thinking is that when protein is scarce the inflamatory systems gear back to conserve fuel makes sense in evolutionary terms.
Keller et al..will be publishing more on this later with a major article comming I believe this March in Nature...
":>) JL
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