Doesn't imply that if JAK3 is all you hit (as VRTX does) that you will be OK. It might turn out to be a dosage issue - you can partially inhibit JAK1 and JAK3 say, or you can more fully inhibit JAK3 by itself to get the same efficacy, but maybe with more problems with infections.
When I was talking about the INCY compound I did not mean their myelofibrosis compound - I meant their RA version:
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