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DewDiligence

10/21/11 12:10 PM

#128947 RE: jq1234 #128945

It remains to be seen whether ribavirin will be part of ABT’s all-oral HCV combination, when all is said and done. The components will likely include ABT-450 (a PI), ABT-267 (an NS5A inhibitor), and one of the non-nukes (ABT-072 or ABT-333).

ABT-450 requires boosting with ritonavir, so there are at least four drugs in the cocktail (and possibly five) if you count ritonavir.
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DewDiligence

10/21/11 1:01 PM

#128962 RE: jq1234 #128945

ABT-267 (the NS5A inhibitor) may enable ribavirin to be ditched from ABT’s all-oral cocktail.

Addendum: ABT-267 might be the same drug as Enanta’s EDP-239 (#msg-47301187). I’m not sure about this, but I will try to find out.