The 10b5-1 plans are a bearish signal, but a very weak one, IMO.
As noted in my prior post, there are companies such as CLB where insiders have sold colossal amounts of company stock. If MNTA's insiders were doing that, I would be concerned.
Maybe the exception but a good analog is UTHR... and they gave out options like crazy for years, I was pretty happy with my return on that stock though for YEARS people complained about their options and selling. My take is executives know they are going to be getting more shares and have their own comfort level for how many shares they want to hold.
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