Replies to post #395578 on Zeev's Turnips Patch-No Politics (ZEEV)

[marginnayan]

EYET - MUST READ (from Yahoo)


"This is not old news"

"The fact that macugen is a specific blocker of EGF receptor isoform 165 and 121 which are the prevalent receptors in the eye is an extremely important factor about determinig the side effects when any EGFR blockers is used clinically.
you have to remeber that EGF has an important physiological function in the body.That is why it evolved.
for eg:1 When EGFR is blocked in the lungs it leeds to lungcell apoptosis and emphysema
2 In coronary artery disease when an artery is clogged and blocked the development of natural by passes -collateral-circulation depends on EGF
3 The same is true in brain and oter organs

In short EGFs are a powerful(50000)times more powerful than histamine in certain chemical activities. They have far reching effect in human body and indiscriminate non selective bolckade like caused by a nonspecific drug LUCENTIS may have terrible side effect when widely used. Remember the Tragedy of Thalidomide1

http://finance.messages.yahoo.com/bbs?.mm=FN&action=m&board=1607685533&tid=eyet&sid=....

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