A guarantee, one 20-megaton or so nuclear bomb used on a human populace, just one; will set off a chain of events that will collapse the modern world.
That applies even if there is NO subsequent nuclear bomb used.
It doesn't matter who does the deed or against whom the deed is directed.
There is someone that writes now an then most excellent posts, his handle is Migo.
He holds that economics underly all historical hostility.
I will go further and state the world economic today is a tight-rope walker with one hand tied behind its' back trying to cross a rope into a a light headwind.
Any , of what we call "exogenous" events, were to cause a 100mph gust on this tightrope walker and down he will fall to be broken with terminal hemorrghaging on the Rocks of Conclusion.
What i describe at the beginning would produce that 100-MPH gust.