9:10AM Seattle Genetics presents sgn-75 clinical data at ASCO Annual Meeting (SGEN) 18.94 : Among 25 RCC patients treated at escalating doses of SGN-75, two patients achieved a partial response, eight patients had stable disease, 11 patients had progressive disease and four patients were not evaluable for response. At doses of 2.0 milligrams per kilogram (mg/kg) and higher, two of nine patients with RCC who were evaluated for response achieved partial remissions lasting 23 weeks and 19+ weeks. Among 16 non-Hodgkin lymphoma patients treated with escalating doses of SGN-75, one patient with mantle cell lymphoma achieved a complete remission with duration of 31 weeks... The most common adverse events associated with SGN-75 treatment in the every three week dosing regimen were fatigue (30 percent), nausea (30 percent), dry eye (23 percent) and thrombocytopenia (23 percent). The maximum tolerated dose was determined to be 3.0 mg/kg every three weeks. Based on the observed ADC half life of six to 10 days, increased patient convenience and better safety profile, the every three week dosing schedule has been selected for further study. Enrollment of additional patients in up to 15-patient disease-specific cohorts is continuing at the 3.0 mg/kg every three week dose to further elucidate the safety and antitumor activity of SGN-75.
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