Replies to post #117730 on Biotech Values

[dewophile]

i'm not convinced you need SVR data to move to 3 agents - if it becomes clear (and it's starting to) that a 3rd agent is necessary all you need is requisite safety data
that said your timeline is probably more accurate than mine

[DewDiligence]

Elaborating on your point about protocol tweaking, trials with three unapproved drugs in combination will likely need at least five arms: the triple combination, each of the three double combinations (to ensure that each drug in the triple is actually needed), and a control arm.