Indeed. I was honestly a little surprised at how little we understand about the mechanism of bone mets given this has been a known phenomenon for mostly ever and we've had drugs available for this for quite some time. Lots of theories, but also lots of opposite theories that make sense.
I have to say, and I'm as much a fan of diving into the scientific weeds as anyone I know, it was a little head-spinning going through all the research. The clearest research is on osteosarcoma. The issue is whether you can draw a bright line between osteosarcoma and bone involvement of disease that initiates in soft tissues.
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