>>For a second I was concerned that enrollment would take a year, but then…<<
I think the one-year guidance for enrollment in today’s PR is the same as prior guidance –it’s just stated differently by combining the setup time with the actual recruitment time: #msg-5771910.
>>I realized that in 25 yrs of medical practice I have yet to encounter a creature in whom I was aware of the anti-thrombin deficiency diagnosis. So, it may take that long to not only find the creatures, but wait for them to have a high-risk procedure or pregnancy.<<
GTCB has listed a trial on centerwatch and clinicaltrials.gov, which is a reasonable way to recruit people with rare diseases. This trial is no longer recruiting patients, so it's not the trial they just announced.
It's a pretty rare condition, so it's not surprising you haven't come across it.
"Antithrombin deficiency is present in 0.17% of the general population. 6 It accounts for 1.1% of unselected patients with venous thrombosis and up to 5% of patients younger than age 70 years with thrombosis. 7,8 Over 127 mutations in the antithrombin gene are known to cause hereditary antithrombin deficiency. 9" http://www.mgh.harvard.edu/labmed/lab/coag/handbook/CO000300.htm
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