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DewDiligence

12/03/10 1:44 PM

#109897 RE: jq1234 #109896

The XL184 program has more than its share of red flags, IMO. I found the giddiness on EXEL’s recent webcasts off-putting, and I question the degree to which supposedly independent clinicians participated in these investor-oriented events.

I previously commented on the deficiencies of the RDT design, which is essentially a brute-force way to enrich a clinical trial when a company doesn’t know how to find a biomarker.

All told, EXEL strikes me as a company that’s desperately and prematurely trying to sell XL184 to the investment community as a cancer drug with Avastin-like upside. That could conceivably happen, but the odds are very much against it.