Wow, if those numbers surprise you, then Yoda, make sure you are sitting down when you learn the reality of the TDM-1 reaction efficiency. TDM-1 is a mixture of conjugates with varying levels of the attached drug, mytansinoid-1 aka M-1. M-1 is attached at lysine residues of which there are 86 scattered throughout the heavy and light chains. So there are 86 potential sites of conjugation on any given antibody, but in reality only 40 have been seen to be available. The range has been 1-6 M-1 molecules per antibody, with an average of 3.5.
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