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BTH

08/27/10 10:50 AM

#102715 RE: drbio45 #102704

I don't know why it worked better than nexavar



It worked better than Nexavar because Nexavar is another crap MULTI-TARGETED Kinase inhibitor.

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rkrw

08/27/10 11:12 AM

#102717 RE: drbio45 #102704

PLX4032 was designed to target a very specific mutation, the BRAF v600e mutation, they screen patients for this mutation.

It's not a matter of nexavar being a crappy multi kinase drug (to quote BTH's flippant remark), nexavar wasn't designed to hit that mutation.