Macugen .3mg vs 3mg
<<Are they saying at the 3mg dosage that .3mg where in the blood after the injection?>>
I assumed her comments refered to the fact that .3mg is the contemplated recommended dosage level, whereas one of the trial arms was treated at 3mg. This is an assumption, however.
<<If eyet drug has a half life of 10 days at .3mg and squalamine has a half life of 4 hours at 40mg are we saying that in less then 2 days there is more of macugens drug in the blood stream then their would be squalamine?>>
I have no expertise on this, but it seems to me that any inferences about squalamine blood level versus macugen blood level would be very difficult due to IV versus intravitreal administration, as well as differences in molecules.
Perhaps someone knowledgeable could venture an educated answer.
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