<<<Comparing the acceptable limits of toxicity for squalamine in cancer trials to that in AMD is a non-issue, because the acceptable side-effects for cancer drugs are beyond the pale for almost any other medical indication.>>>
Do you think systemic delivery of squal for amd is a non approvable concept?
Wet AMD is a serious and devastating disease. I know someone that has it. Vibrant guy, barely above middle age, electrician, losing his vision, worried about losing his independence and ability to support himself. This is a horrible disease. It's a wide open opp, tremendous demographics and no surprise there's a gold rush of bio's and pharma trying to come up with better therapies.
As with any other disease, is the efficacy meaningful and do the benefit outweigh the side effects? Who knows?
*I have no position in genr. I'm no big fan. But systemic delivery makes it an intriguing program to follow and I'm looking forward to seeing the placebo controlled data.
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