Replies to post #94912 on Biotech Values

[genisi]

On BCX-4208 safety

this PNP inhibitor’s ability to reduce uric acid levels in the blood

But it also suppress the immune system (T and B cells). Similar to the gout trial, in the phase IIa trial in psoriasis BCX-4208 was generally safe and well-tolerated at doses up to 120 mg daily for 6 weeks. However, the suppressive effect on the immune system probably takes longer to manifest itself.