I suspect the culture has changed quite a bit from when TKT Europe was doing the selling and holding its own quite nicely against Genzyme... Even still I think if I were Ms. Lipez I would find a new doc!
Considering how long and the numerous problems I am not sure what has surprised me more that Genzyme's stock price hasn't drop more (to what I would consider an attractive price) or Henri Termeer stepping down. On second thought he seems to have a big ego/love of power and I think he is not the type to just step aside.