Replies to post #47087 on Avid Bioservices Inc (CDMO)

[cjgaddy]

FF, your #47087 is a terrific overview of Bavi's Anti-Cancer moa, especially bringing to light why Bavi appears to have such potential against Refractory/Chemo-Resistant tumors, the very target of the new ‘registrational’ Ph.2 Bavi+Doce/2nd-Line-NSCLC trial put together by RGarnick, S.King & Team. If you don't mind, I'm going to add your post to the end of my "Peregrine’s Ambitious Bavi Goal: Accelerated Approval after PhaseII” post from yesterday, so it’ll be there when I update it when significant news events/updates occur down the road. Much thanks.

[TXDESERTFOX]

Whatever happened to the use of Bavi as a diagnostic tool in "lighting up" tumors?

[entdoc]

firefox, I watched the Thorpe video again and did not see this quote you printed: "One end of the Bavi MAb sticks to the PS. The other end of the Bavi MAb is called the FC Receptor and is wagging in the breeze as various white cells in the blood supply float buy. These white cells (in particular Macrophage and Natural Killer Cells) stick to the FC Receptor on Bavi and immediately cause a cytotoxic reaction that “attacks and destroys the tumor blood vessels”. Do you have a reference to that MOA, that macrophages stick to the FC Receptor? We need to use that FC receptor to carry a payload to kill residual tumor cells left over after the blood supply is cut off. Just a thought.