I'm replying to this post because I searched the values board for "BNVI" and this is the most recent post of 2 from all of 2009.
Neat strategy for killing cancer cells, inhibit glycolysis.
Chart is a classic "waking monster formation :^)
I don't have any yet because I don't have cash.
Bezielle® for the Treatment of Advanced Breast Cancer
Background
There are currently no effective therapeutic cures for advanced breast cancer and treatment is primarily aimed at palliation of symptoms as well as improving overall survival. Approximately 200,000 women are diagnosed with breast cancer each year and breast cancer is the second leading cause of cancer death among women. Although survival after breast cancer treatment is improving, there are still over 40,000 deaths per year due to the disease. The annual market for drugs targeted at this disease is estimated at $7 billion.
Mechanism of Action
Bezielle is an oral drug designed for the treatment of advanced breast cancer with a novel mechanism of action. Bezielle targets diseased cells while leaving normal cells healthy and intact. Normal cells depend primarily on the citric acid cycle (>85%) and very little on glycolysis (<7%) for energy production. In contrast, cancer cells depend largely on glycolysis (>85%) for energy production. Bezielle induces strong oxidative stress in cancer cells leading to severe DNA damage, but in normal cells the effect is blunted due to their different metabolic profile. Cancer cells attempt but ultimately fail to repair DNA damage that results in the inhibition of glycolysis and cancer cell death while normal cells remain unharmed.
Selective Cytotoxic Activity
Bezielle is selectively cytotoxic to most of twelve breast cancer cell lines examined, as well as to a number of cancer cell lines of different tissue origins such as prostate, lung, colon and pancreatic cancers. At the same dose, Bezielle does not induce appreciable cell death in normal cells such as fibroblasts and normal mammary epithelial cells and lines. Bezielle was also orally active in preventing tumor formation in a mouse xenograph model.
Phase 1 Clinical Results
Bionovo’s lead cancer candidate has been evaluated in two Phase 1 clinical trials and a total of 47 women with advanced breast cancer have been treated with Bezielle. Data from the Phase 1 clinical trials of Bezielle show promising signs of efficacy and indicate the drug is well tolerated and safe for clinical use.
Next Steps: Phase 2 Clinical Trial
A multi-center, Phase 2, open-label, non-randomized clinical trial to assess ongoing safety and preliminary efficacy of Bezielle for the treatment of metastatic breast cancer is being conducted under the co-directorship of Dr. Banu Arun of the M.D. Anderson Cancer Center and Alejandra Perez of the Memorial Cancer Institute. A total of 80 women with histologically confirmed breast cancer and measurable stage IV disease will be enrolled to the Phase 2 trial. Of the 80 women, 40 will have hormone receptor-positive disease and 40 will have hormone receptor-negative disease. The primary outcome measure will be response to therapy evaluated by the Response Evaluation Criteria in Solid Tumors (RECIST). Secondary measures of efficacy will include: duration of overall objective response, progression-free survival, overall survival, and patient reported quality of life measures. Recruitment for the clinical trial will take place at 15 clinical sites throughout the United States. Click here to visit Bionovo's Bezielle clinical trial website.
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