[Officer/director holdings are as of today and include restricted stock and options, whether or not vested. Institutional holdings are as reported on Form 13G as of 12/31/08 unless otherwise indicated. Percentages shown below are based on 49.1M diluted shares and hence they may differ from percentages reported in SEC filings.]
Shares Stake Novartis 4,708,679 9.6% Visium Asset Mgmt 3,349,122 6.8% T Rowe Price 3,338,081 6.8% Samana Capital 2,109,760 4.3% Federated Investors 1,381,457† 2.8% R. Langer (Ex-director) 1,066,022 2.7% Craig Wheeler (CEO) 987,344 2.0% Alan Crane (Director) 652,202 1.3% G. Venkataraman (SVP, R&D) 628,540 1.2% Ram Sasisekharan (Director) 517,344 1.0%