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cosmiclifeform

10/05/04 2:25 PM

#17820 RE: frogdreaming #17810

Frog - Therein lies the difference in our world views and investment strategies...

You continue to believe DNAP is only a "pipedream"...

I continue to believe DNAP has a growing "drug pipeline"...

Biofontera's projects at the preclinical research stage include:

Cathepsin inhibitors

Inhibitors for protease activated receptors

Inhibitors for sphingomyelinase

Kinase inhibitors

Biofrontera's projects at the preclinical development stage include"

5-HT2B receptor inhibitor for migraine prophylaxis

Biofrontera's projects at the clinical development stage include:

Histidine decarboxylase inhibitor (Phase II)

Skin cancer drug (Phase II, inlicensing deal currently closed)

DNAPrint's projects include

Ovanome - Taxol/Carboplatin efficacy

Statnome - Lipitor, Zocor, efficacy

Statnome Muscle - Lipitor, Zocor adverse myalgia response

Acenome - Enalapril, Lisinopril efficacy

Acenome Musc - Enalapril, Lisinopril adverse cough

Immunosuppressants - Sirolimus, Tacrolimus, Mycophenolate mofetil efficacy in transplant patients

DNAP/Moffitt projects:

1) Response of Metastatic Colorectal Cancer to Irinotecan/Capecitabine (Xeliri) and Oxaliplatin/Capecitabine (Xelox)

2) Melphalan and Topotecan (MT) efficacy for treatment of Multiple Myeloma

3) Cyclophosphamide efficacy

4) Organistron adverse events - post operative nausea and vomiting

5) Esophageal malignancy chemotherapy response - standard FDA treatment

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While these may be "pipedreams" to you, they are real research projects leading to new drugs and drug classifiers...a VERY substantial "drug pipeline" for DNAP and all us DNAP investors...

Obviously we continue to see (and value) the world differently...and that's ok...

On the other hand, in spite of your pessimism and constant doom and gloom about DNAP....you ARE still here after 4 years.

I take that as a very good sign that DNAP offers you something for you to stick around so long...

I wish you as much success with your "pipedreams" as I do for DNAP's "drug pipeline"...

Take care,

Robert