Asthma indication is different since there will be less systemic exposure. I think syk inhibitors will be plagued with neutropenia and hypertension issues when the data come out.
I just found out that SNTA has an oral RA drug in Phase 2a trials called apilimod, with results due by the end of this year. This is an oral IL-12/IL-23 inhibitor. However, I listened to the 5/18/09 Deutsche Bank conference webcast and the presenter effectively said that they have obeserved some "pharmaceutical properties that are not optimized" so I guess that means you can pretty much scratch that one.
Re: Oral RA/Autoimmune Drugs I am remembering SCIOS having a P38 inhibitor in human clinical trials it was called SCIO-469. I did a quick search of the FDA database and there are some trials still listed. I have no idea if JNJ has completely squashed the program or not. SCIOS was not one of their better acquisitions. Although I made a lot of money. :)
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