Replies to post #37415 on Avid Bioservices Inc (CDMO)

[keep_trying]

2ndstr2thert, good questions. Jazz has typically done duty with such technical questions but I will give it a try. Others more knowledgable about this are free to correct my take on this.

1. Bavi attaches to exposed PS which would normally be internal to a healthy cell. PS itself is not attacked by the immune system because the PS is an amino acid that is a normal part of cell function. Exposed PS is naturally and routinely "cleaned up" by the body through a different mechanism than for the immune system response. The clean up mechanism is not sufficient to prevent tumor growth. Once Bavi is attached to the exposed PS, the immune system recognizes the Bavi as a foreign substance for removal and an immune response is initiated.

2. In the process of "attacking" the exposed PS linked with Bavi, the immune system response interacts with the cancer cell vasculature, cutting off blood flow to the tumor cells which die and are removed through the body's clean up mechanism.

In the case of enveloped viruses, Bavi targets the exposed PS of the cells that were invaded by the virus plus Bavi attaches to the exposed PS that is mixed with the "coating" or envelope of cell matter that the virus carried from the host cell. The PS envelope that was shielding the virus from an immune response is labeled by Bavi, effectively uncloaking the virus and allowing the body's immune system to recognize the virus invader and mount an attack.

Does this explanation make sense to you?

Best wishes and IMO.
KT

[slipperypete]

PS that is exposed is sending out a immune suppression signal this is
not a problem if it is just normal cell death. However, with cancer and viral disease there is huge cell death resulting in the exposure of PS on a large scale. This in turn sends out a huge signal to suppress immune system. Therefore, human immune system does fight the disease.


You should do your own DD. Have fun reading.

JMO
SP

[rattlewatch]

Thanks for the posts. IMO,The market clearly responded to the Cotara update. Have read your previous posts and this portion of one of your posts stands out.

gl
rw

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I don't think anyone knows how effective Cotara can be in treating any and all solid tumors ( maybe the Chinese do ). I understand that trials need parameters but keep in mind that Cotara becomes more effective with each dose. It also has several advantages over Bavi:
1) It does not depend on the immune system for efficacy.
2) Even though Bavi can destroy tumor vasculature the tumor may still feed off the tissue near its periphery ---Cotara destroys tumors from the inside out.
3) Cotara has been approved for phase 3( albeit a different mode of delivery )
4) Cotara hasd been approved for "Orphan Drug and Fast Track " status.

Of course Cotara has radiation complications that Bavi doesn't but the focus should be on the possible synergestic effects achieveable when all of Tustin's tech is used together.
One last comment---I don't know how culpable Dr. Epstein is , but I would be fuming if my lifes work was in Tustin's hands---I HOPE Dr. Thorpe does not become disenchanted.

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