Replies to post #8221 on Entremed (ENMD)

[docaaron1]

C_Peptide, I think they are finally starting to get it. The Combo-Mambo is the way to go.
If I'm not mistaken downstream of the "downstream players, like NF-kB and mTOR" is HIF-1a.

So IMO even if the tumor is not highly angiogenic, your Avastin/Panzem combo would still be called for since Panzem is a potent HIF-1a inhibitor.

Also IMO you have to give Panzem a head start so that Avastin (or other combo drug) won't trigger the HIF-1a rebound effect to levels greater than Panzem can handle.

How early to start Panzem? My guess is a week to a month. However, the best point to add the combo drug may be as simple as looking when a tumor starts to stabilize with Panzem and then start adding the combo drug. Ironically IMO the one Panzem combo trial (Panzem/Temodar) that closed may have responded the best to the Panzem head start method.

Just some thoughts,
Aaron

P.S. Combo-Mambo may not apply to ENMD 2076. Not enough published data yet.