Replies to post #75070 on Biotech Values

[mcbio]

Re: ACHN IDIX HCV-protease selectivity

IDX136/316, IDIX’s PI’s, have essentially no activity against the most important host proteases.

Thanks for the info Dew. Is ACHN's claim of >4000 fold selectivity against human proteases akin to saying "no inhibition" of human proteases, or otherwise close? I'm just trying to get an idea of the significance of the "4000" number and how it stacks up to IDIX's claims for its PIs.

Also, IDIX states that there is no inhibition of 8 human cellular proteases for its PIs. I'm just curious how many proteases there are in total.