Replies to post #74610 on Biotech Values

[poorgradstudent]

THLD:

>From my understanding .6% O2 is what they were studying.<

So here is my question (concern?):

Atmospheric pressure is 760 mm Hg, of which 21% is O2, so the partial pressure of O2 is 159.6 mM Hg. At 0.6%, the partial pressure is 4.56 mM Hg. That's less than half the 10 mm Hg that was used to delineate hypoxic tumours from other types of tumours.

So does the partial pressure of O2 in the tumour drop to less than 5 mM Hg? What percentage of pro-drug is released when it is 10 mm Hg?

>Also in resposne to TH-302's prodrug being similar to TELK's I did a little digging and the prodrug parts are very different.<

I absolutely don't doubt that the prodrug parts are very different, since they're putatively cleaved / activated by different mechanisms. But the prodrug doesn't do anything, so that's not relevant to efficacy. The important question is whether the active moieties are functionally the same? (To which the answer is: yes)