Now I will concede that different distributors and middlemen can effectively change prices by 2-4%.
You seem to be focusing on retail prices, which are irrelevant to our discussion inasmuch as we’re talking about calculating the ASP for the manufacturer. Variations in the ASP for the manufacturer according to the location and the middlemen are about an order of magnitude greater than the 2-4% range you cited, i.e. they’re as large as 40%.
The good news for BIIB and ELN is that Tysabri sales did not decline from quarter to quarter, as they did from 3Q08 to 4Q08 (#msg-35397974). The bad news for BIIB and ELN is that sales growth from 4Q08 to 1Q09 was almost non-existent in the US.