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Replies to #69486 on Biotech Values
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iwfal

12/04/08 7:32 PM

#69490 RE: mcbio #69486

I assume by "events" you are referring to patient deaths. Wouldn't the company still be able to report a p-value even if there were few deaths/events? Just wondering if there's any chance that they didn't because the p-value may have been greater than .05 at this point (i.e. not stat sig).

That is, in fact, one of the points of my previous post. If there is no mention of "stat sig" then p was almost certainly greater than 0.05. Just the way companies seem to work.

Also, is it a valid concern to wonder if these results only pertain to a few deaths/events?

? Not sure what you are asking different than I already expressed. If HR=0.60 on a trial with 40 patients per arm then only a small percentage of patients could have died so far. As a greater percentage die the HR and the p value will change.

The more interesting point is that they gave enough data to hint that the HR through, say, 20 months was a lot better than 0.60.